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Bone Healing Evaluation in Critical-Size Defects Treated With Xenogenous Bone Plus Porcine Collagen

Maciel, Juceléia DDS, MSc; Momesso, Gustavo Antonio Correa DDS, MSc; Ramalho-Ferreira, Gabriel DDS, MSc, PhD; Consolaro, Renata Bianco DDS, MSc, PhD; Perri de Carvalho, Paulo Sérgio DDS, MSc, PhD; Faverani, Leonardo Perez DDS, MSc, PhD; Farnezi Bassi, Ana Paula DDS, MSc, PhD

doi: 10.1097/ID.0000000000000572
Basic and Clinical Research
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Purpose: This study aimed to evaluate the osteoconductive features of Bio-Oss Collagen in large critical-size defects (8 mm).

Materials and Methods: Thirty-six adult Wistar Albinus male adult rats were carried out a critical-size defect with a trephine bur of 8 mm in the calvaria. Groups were divided depending on the filling biomaterial as follows: group BO: Bio-Oss (n = 18); group BOC: Bio-Oss Collagen (n = 18). After 7, 30, and 60 days, 6 rats of each group were euthanized with anesthetic overdose. Specimens were laboratory processed for histomorphometric analysis. Histomorphometric data were statistically analyzed by analysis of variance and post-Tukey test (P < 0.05).

Results: Statistical differences were found in new bone formation just in the intragroup comparison among periods after 7 and 60 postoperative days, indicating more new bone formation after 60 days (Tukey test, P = 0.029).

Conclusion: Under the limitation of this research, it could be concluded that Bio-Oss and Bio-Oss Collagen in this experimental model did not show osteoconductive features.

*PhD Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil.

MSc Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil.

Assistant Professor, Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil.

§Full Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil; Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil.

Assistant Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil.

Reprint requests and correspondence to: Gustavo Antonio Correa Momesso, DDS, MSc, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Rua José Bonifácio, 1193, Vila Mendonça, Araçatuba, São Paulo 16015-050, Brasil, Phone: (+55) (18) 3636-3270, E-mail: gustavomomesso@gmail.com

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