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Statins, Glucocorticoids, and Nonsteroidal Anti-Inflammatory Drugs: Their Influence on Implant Healing

Fu, Jia-Hui BDS, MS*; Bashutski, Jill D. MS, DDS; Al-Hezaimi, Khalid MS, BDS; Wang, Hom-Lay DDS, MsD, PhD§

doi: 10.1097/ID.0b013e3182611ff6
Clinical Science and Techniques
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This article aimed at exploring the effects of common systemic medications used in the United States and their effects on periimplant bone healing. An electronic search for articles evaluating the influence of systemic medications on periimplant bone healing was conducted using the PubMed (MEDLINE) database. Statins, when administered locally or systemically, were found to increase bone formation and density. A reduction in bone turnover and bone-to-implant contact was observed in animal models examining the effect of glucocorticoids on periimplant bone healing. Continued use of nonsteroidal anti-inflammatory drugs (NSAIDs) during or after implant placement was associated with reduced bone-to-implant contact, bone area, and bone density. Evidence seems to suggest that statins improve implant osseointegration. However, glucocorticoids and NSAIDs showed conflicting results. Therefore, more randomized clinical trials are needed to validate the effect of glucocorticoids and NSAIDs on periimplant bone healing.

*Assistant Professor, Department of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore.

Clinical Assistant Professor and Discipline Coordinator of Undergraduate Periodontics, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.

Assistant Professor and Chair, Eng. A. B. Research Chair for Growth Factors and Bone Regeneration, King Saud University, Riyadh, Saudi Arabia.

§Professor and Director of Graduate Periodontics, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI; Research Advisor, Eng. A. B. Research Chair for Growth Factors and Bone Regeneration, King Saud University, Riyadh, Saudi Arabia.

Reprint requests and correspondence to: Hom-Lay Wang, DDS, MsD, PhD, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109-1078, Phone: 734-763-3383; Fax: 734-936-0374; E-mail: homlay@umich.edu

© 2012 Lippincott Williams & Wilkins, Inc.