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Evaluation of Periimplant Crevicular Fluid Prostaglandin E2 and Matrix Metalloproteinase-8 Levels From Health to Periimplant Disease Status: A Prospective Study

Basegmez, Cansu DDS, PhD*; Yalcin, Serdar DDS, PhD; Yalcin, Funda DDS, PhD; Ersanli, Selim DDS, PhD§; Mijiritsky, Eitan DMD

doi: 10.1097/ID.0b013e3182588408
Basic and Clinical Research
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Objective: To compare the levels of prostaglandin E2 (PGE2) and matrix metalloproteinases-8 (MMP-8) in periimplant crevicular fluid (PICF) after osseointegration and loading.

Materials and Methods: PICF was collected at the 3rd, 6th, 12th, and 18th months after implantation of 72 implants. PGE2 and MMP-8 levels besides clinical parameters were evaluated.

Results: Plaque and gingival index at the 6th, 12th, and 18th months presented higher values. Probing depth showed an increase after the 12th month. PGE2 presented a higher value at the 18th month. MMP-8 level demonstrated higher values after the sixth month. PGE2 and MMP-8 demonstrated positive correlations with gingival index and probing depth.

Conclusion: The detection of PGE2 and MMP-8 in PICF serve to be useful for monitoring the course of periimplant disease. MMP-8 promises to be an early signal of periimplant inflammation.

*Researcher, Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Turkey.

Professor, Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Turkey.

Professor, Department of Periodontology, Faculty of Dentistry, Istanbul University, Turkey.

§Associate Professor, Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Turkey.

Department of Oral Rehabilitation, The Maurice and Gabriela Goldschlager School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Reprint requests and correspondence to: Cansu Basegmez, DDS, PhD, Istanbul University Faculty of Dentistry, Department of Oral Implantology, 34390 Capa Istanbul, Turkey, Phone: +90-212-532-3218, Fax: +90-212-532-3254, e-mail: cansu.basegmez@gmail.com

© 2012 Lippincott Williams & Wilkins, Inc.