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Ridge Bone Maintenance in Human After Extraction

Casado, Priscila Ladeira PhD*; Duarte, Maria Eugênia Leite PhD; Carvalho, Waldimir MSD; Esmeraldo da Silva, Licinio MSc§; Barboza, Eliane Porto DSc

doi: 10.1097/ID.0b013e3181dec322
Basic and Clinical Research

Purpose: The aim of this study was to evaluate, clinically and histologically, the tissues formed in human alveolar sockets filled with bovine morphogenetic protein/bovine organic matrix (BOM) and absorbable membrane (AM) immediately after extraction.

Materials: Forty-six human alveolar sockets, exhibiting buccal bone defects were selected for this study. Group 1 received no biomaterial to serve as control. Sockets from group 2 were filled with bovine bone morphogenetic protein (bBMP) associated with bOM. The association of bBMP/bOM/AM filled the alveolar defects from group 3. AM was placed over the defects from group 4. Clinical evaluation analyzed ridge width before biomaterial filling and 4 months after filling. Fifteen specimens were collected from groups 2, 3, and 4 for histologic analyses.

Results: Clinical results showed no significant augmentation on the control group (−0.16 ± 0.28 mm). All test sites, groups 2, 3, and 4, showed relevant ridge width augmentation (3.0 ± 0.5 mm, 2.4 ± 0.3 mm, and 2.9 ± 0.6 mm, respectively) and no resorption. Histologically, all experimental alveolar sockets showed active bone formation with osteoid, osteoblasts, and cell differentiation.

Conclusion: On the basis of this study, we concluded that bBMP/bOM with or without AM could preserve the ridge showing viable bone formation for future implant placement.

*Professor, Department of Master Course in Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil.

†Professor, Department of Cell Culture - National Institute of Traumatology and Orthopedics, Brazil.

‡Professor, Department of Prosthodontics, Federal Fluminense University, Rio de Janeiro, Brazil.

§Professor, Department of Statistical, Federal Fluminense University, Rio de Janeiro, Brazil.

∥Professor, Federal Fluminense University and Brazilian Institute of Periodontology, Rio de Janeiro, Brazil.

Reprint requests and correspondence to: Priscila Ladeira Casado, MSD, Rua Gavião Peixoto 148 sala 1101–Icaraí–Niterói–RJ CEP: 24230-101 Fax: +55-21-2621-6797, Phone: 55-21-2704-0995. E-mail:

© 2010 Lippincott Williams & Wilkins, Inc.