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Microvessel Density in Alveolar Ridge Regeneration with Autologous and Alloplastic Bone

Piattelli, Adriano MD, DDS*; Degidi, Marco MD, DDS**; Alessio Di Stefano, Danilo DDS***; Rubini, Corrado MD; Fioroni, Massimiliano DDS; Strocchi, Rita MD§

Basic and Clinical Research

Purpose The purpose of this study was to conduct a comparative immunohistochemical evaluation of microvessel density (MVD) in alveolar sites augmented with autologous bone or Bio-Oss.

Materials and Methods Eighteen patients participated in this study. All patients presented maxillary ridge defects. These defects were filled in a random fashion with autologous bone or Bio-Oss. Endosseous implants were inserted after a mean of 3 months in the sites augmented with autologous bone and after a mean of 6 months in the sites augmented with Bio-Oss. As part of the implant site preparation, a trephine was used to harvest bone cores. As control, bone cores retrieved in nonaugmented sites were used. The mean value of MVD in control bone was 25.6 ± 3.425. In the sites augmented with autologous bone, the MVD was 29.8 ± 4.4, while in the sites regenerated with Bio-Oss, the MVD was 29.7 ± 2.4. The statistical analysis showed that the difference in MVD between control bone and autologous bone (P = 0.057) and between control bone and Bio-Oss (P = 0.023) was statistically significant. The difference between the sites regenerated with autologous bone and those regenerated with Bio-Oss was not significant (P = 0.6889).

Conclusions Our results show that both sites augmented with autologous bone and Bio-Oss presented a higher and statistically significant quantity of microvessels compared with control specimens. No significant differences were found when comparing the MVD of the sites regenerated with autologous bone and those regenerated with Bio-Oss. The retrieval time was, however, a mean of 3 months for the autologous bone sites and a mean of 6 months for the Bio-Oss sites. These data could support the hypothesis of faster healing for the sites augmented with autologous bone.

*Professor of Oral Pathology and Medicine, Dental School, University of Chieti, Italy.

**Visiting Professor, Dental School, University of Chieti; Private Practice, Bologna, Italy.

***Visiting Professor, Dental School, University of Chieti; Private Practice, Trezzano sul Naviglio (Milano), Italy.

†Researcher, Department of Pathologic Anatomy and Histopathology, University of Ancona, Italy.

‡Dental School, University of Ancona, Italy.

§Professor of Anatomy, Dental School, University of Chieti, Italy.

Reprint requests and correspondence to:

Prof. Adriano Piattelli, MD, DDS

Via F. Sciucchi 63

66100 Chieti, Italy

Fax: 011-39-0871-3554076

E-mail: apiattelli@unich.it

© 2002 Lippincott Williams & Wilkins, Inc.