Foon K.; Doroshow, J.; Bonnem, E.; Fefer, A.; Graham, S.; Grosh, B.Journal of Biological Response Modifiers: December 1988 Short Communication: PDF Only Buy Abstract Summary Eighty-nine patients with advanced measurable metastatic renal cell carcinoma were entered into a prospective randomized trial comparing alpha-interferon to gamma-interferon and to the combination. The trial was performed in order to confirm the activity of gamma-interferon and assess the potential clinical synergism. Response rates were 5, 10, and 5%, respectively. The low response rate may have been due to the inability to raise the doses of the interferons to higher levels. Clinical synergy at this dose, route, and schedule of administration in renal cell carcinoma does not exist. © Lippincott-Raven Publishers.