Short Communication: PDF OnlyChen Benjamin P.; Sondel, Paul M.Journal of Biological Response Modifiers: August 1986 - p 351-361 Buy Abstract Summary The immunomodulatory effect of two highly purified recombinant human interferons (IFN) on T cell-mediated cytotoxicity of autologous Epstein-Barr virus-transformed B cells (EBV-LCL) was assessed. Interferon βser, but not α76, potentiated the destruction mediated by interleukin-2 (IL-2) dependent, long-term T cell cultures. The degree of potentiation of specific cytotoxicity was dependent on the concentration of the exogenously added IFN βser. In contrast to the potentiation of T cell-mediated cytotoxicity, IFN βser and α76 did not modulate the cytotoxic activity of cytotoxic T cell clones that are specifically reactive to autologous EBV-LCL. These results indicate that the selective potentiation of EBV-LCL-reactive T cell-mediated cytotoxicity by IFN βser may not be due to a direct IFN effect on the cytotoxic T cells (CTLs) themselves. Rather, our results are consistent with IFN βser augmenting cytotoxic T cell reactivity indirectly, possibly via its influence on other immunoregulatory cells. Although the precise mechanism whereby IFN βser may potentiate cytotoxicity is not yet defined, the synergistic action of IFN βser and IL-2 on long-term CTL cultures offers an alternate means to selectively enhance a desirable cytotoxic response. © Lippincott-Raven Publishers.