Twenty children with hematologic malignancies were treated with bone marrow transplantation using histoincompatible donor marrow depleted of T lymphocytes. CT-2 and complement were used to deplete the T lymphocytes. Engraftment was not a major problem in those receiving increased pre- and posttransplant immunosuppression. Five of the 20 children are currently alive and disease-free. Complications in the other children included engraftment problems, cyclosporin toxicity, infections, and bleeding. However, for most children, durable engraftment was seen. Thus, the nonavailability of histocompatible donors is no longer a contraindication to allogeneic bone marrow transplantation for those at high risk of relapse.
Received April 20, 1985; accepted May 31, 1985.
Address correspondence and reprint requests to Dr. M. E. Trigg at Department of Pediatrics, University Hospital, H4-438, 600 Highland Avenue, Madison, WI 53792, U.S.A.
The results of this study were presented at the following meetings: International Society of Experimental Hematology in London (1983) and in Atlanta (1984) and American Association for Cancer Research in Toronto (1984).
© Lippincott-Raven Publishers.