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Letters to Editor

Amyloidosis of lacrimal gland

Kumar, Vinod; Goel, Neha1; Nicholson, Luke; Shankar, Jai

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Indian Journal of Ophthalmology: Jul–Aug 2010 - Volume 58 - Issue 4 - p 348
doi: 10.4103/0301-4738.64137
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Dear Editor,

We read with interest the article "Amyloidosis of lacrimal gland" by Prabhakaran et al.[1] We would like to congratulate the authors for this well-documented case and would like to make these observations.

The authors report that approximately 24 cases of primary localized amyloidosis of orbit have been reported. However, we believe that this number is likely to be higher. In a review article by Taban et al.,[2] the authors reviewed 31 cases of primary orbital amyloidosis including one of their own. There have been a few further reports after that including a large series by Leibovitch et al.[3]

The authors mention that one bilateral case of isolated lacrimal gland amyloidosis has been reported. We wish to draw attention to one of the cases reported by Cheng et al.,[4] who had bilateral isolated lacrimal gland involvement with amyloidosis. Also, Knowles et al.,[5] have described a case with serial bilateral lacrimal gland amyloidosis without systemic disease (primary localized orbital amyloidosis). This raises the total number of cases previously reported to have bilateral isolated lacrimal gland amyloidosis to at least three.

Hertel's exophthalmometer is designed to measure axial proptosis and is unable to measure ocular displacement. We would value being educated as to how the authors were able to measure the displacement with the help of a Hertel's exophthalmometer. Perhaps the authors are merely implying that apart from having 2 mm of axial proptosis, the patient also had 2 mm of displacement.

Lastly, was any reoccurrence noted? Recurrence has been said to occur in approximately one-third of cases as total excision is usually not possible in these patients.


1. Prabhakaran VC, Babu K, Mahadevan A, Murthy SR. Amyloidosis of lacrimal gland Indian J Ophthalmol. 2009;57:461–3
2. Taban M, Piva A, See RF, Sadun AA, Quiros PA. Review: Orbital amyloidosis Ophthal Plast Reconstr Surg. 2004;20:162–5
3. Leibovitch I, Selva D, Goldberg RA, Sullivan TJ, Saeed P, Davis G, et al Periocular and orbital amyloidosis: Clinical characteristics, management, and outcome Ophthalmology. 2006;113:1657–64
4. Cheng JY, Fong KS, Cheah ES, Choo CT. Lacrimal gland amyloidosis Ophthal Plast Reconstr Surg. 2006;22:306–8
5. Knowles DM 2nd, Jakobiec FA, Rosen M, Howard G. Amyloidosis of the orbit and adnexae Surv Ophthalmol. 1975;19:367–84
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