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Special Focus, Colour Vision

Burden of ocular morbidities and color blindness among school-attending children in a foothill town of Uttarakhand State

Mittal, Sanjeev K,; Mittal, Sunita; Saraswat, Neeraj K; Kishore, Surekha1; Agrawal, Ajai; Singh, Anupam; Samanta, Ramanuj; Bahurupi, Yogesh A2

Author Information
Indian Journal of Ophthalmology: January 2022 - Volume 70 - Issue 1 - p 249-255
doi: 10.4103/ijo.IJO_1677_21
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Abstract

Worldwide there is an estimated 1.4 million blind children among which approximately 73% live in lower income countries.[1] In addition to this, nearly seven million suffer from low vision, and another 10 million have visual impairment with correctable refractive error (refractive bilateral visual acuity of less than 6 by 18.[2] In the pediatric age group, the estimated national prevalence of blindness/low vision is 0.8 per 1000.[3]

In India, 0–15 year’s age group represents approximately 25% of the total population. Schools are the best forum for imparting health education to the children, screening for ocular morbidities, and are also effective in implementing comprehensive eye healthcare programs.[4] Due to wide geographic variability in prevalence and distribution of ocular diseases among school children, there is paucity of reliable population survey-based data on prevalence and distribution of eye diseases among school children especially from developing nations like India. Among the studies conducted in northern India, only a few are from hilly states documenting the prevalence of ocular diseases among school-going children.[56]

A survey among school-going children for color blindness will help us to know its true prevalence and shall be useful for the parents in the counselling of their affected children regarding future career planning. Besides this, several treatable and preventable eye disorders remain undetected till late either due to ignorance or carelessness on part of parents or teachers. Hence, this large, school-based cross-sectional descriptive study was conducted with the aim of estimating the prevalence and distribution of ocular morbidities including color vision among school-going children of age group 6–16 years in foothills of Himalaya. Another objective of this study was to create awareness among the students and their teachers for eye care.

Methods

Demography of study area

As per provisional data of 2011 census of India, Rishikesh town had a population of 1,02,138 with 54,466 males and 47,672 females, while in 2021 Aadhar estimates, it is 322,825. The literacy rate was 86.86% compared to the national average of 74.04%.[7] As per Department of School Education, Doiwala block is subdivided into 13 clusters including Rishikesh. In cluster Rishikesh, there were 87 schools [18 (20.68%) government, 69 (79.31%) private] out of which 83 (95.4%) were coeducational school. In India, difference exists between private and government schools in terms of infrastructure, fees, education level and socioeconomic status, teaching curriculum, and performance pressure. This could lead to variation in the pattern and distribution of ocular morbidities. Since, coeducational schools had nearly equal representation from both sexes and represented 95% of student population, only these were included in the study.

The study was conducted among school-going children of class 1–12 (age group 6–16 years) from selected coeducational government and private schools in the city of Rishikesh over a period of 22 months from April 2018 to February 2020.

For calculating the sample size, we utilized reported prevalence of ocular morbidity 20% (0.20),[8] with 95% confidence level, and absolute precision as 2%. We calculated the minimum sample size required for the study as 1536 school children.

Schools were selected by the cluster sampling technique from varied geographical locations, among the list of all the coeducational government and private schools in Rishikesh. Sixteen private and four government coeducational schools were selected randomly utilizing population proportionate to size methodology.

The approval of Institutional ethical committee was taken. Heads of the selected schools were informed about the study and official written permissions were taken. Parents were also informed about the study by respective school teachers.

All the students studying in class 1–12 (age group 6–16 years) present in the school on the day of examination and willing to participate were included. Those who were either absent or were not willing to participate at the time of survey were excluded.

The study field staff included one ophthalmologist and one optometrist. Interview methods in Hindi, English, or local vernacular language were adopted for recording of data from class teachers or students. Pretested, predesigned semistructured questionnaires were used to collect information on sociodemographic factors like age, sex, class or standard, Chief or specific ocular complaints (single/multiple), and past history of any ocular disease. Ocular examinations were performed in the respective school campus in a clean, quiet, well-lit room with adequate length, preferably longer than 20 feet. All children present in the class on the day of examination were screened following a standard wise pattern in ascending order with the help of an attendance register. Visual acuity (unaided and aided) was assessed using Snellen’s chart available in both English and Hindi including animal optotypes kept at a distance of 6 m. Possible refractive error was assessed by measurement of distant VA using pinhole. Color vision was tested using Ishihara-colored plates in children with visual acuity better than 20/200 in broad-daylight. Assessment of strabismus was done by Hirschberg corneal reflex test for manifest squint, uniocular or binocular extraocular movements, and cover–uncover test for latent and manifest strabismus. Gross anterior segment examination including the lids, lacrimal sac, conjunctiva, cornea, anterior chamber, pupil, iris, lens, and convergence was done using a torch light to rule out any abnormality. The presence of any congenital ocular disorders such as ptosis, nasolacrimal duct obstruction, and congenital cataract was also noted. Other ocular conditions like conjunctivitis, stye, chalazion, corneal scars/opacities, etc., were also looked for. Undilated fundus examination of every child was done using small pupil aperture of a direct ophthalmoscope. Those students requiring dilated fundus examination, cycloplegic refraction, postmydriatic test, or any further detailed evaluation were referred to our tertiary care hospital or to nearby Government hospitals. Teachers and parents, if available were also counselled for the children with any detectable ocular abnormality.

Both visually impairing and nonvisually impairing ocular pathologic conditions were defined as ocular morbidities. Refractive error was diagnosed for unaided VA worse than 6/9 in any one eye, which improved on pin hole testing. Convergence insufficiency was tested using a pen tip and noting a near point of convergence. A diagnosis of defective color vision was made if a cooperative child made five or more errors in reading first 21 plates of 38 plates Ishihara chart. Allergic conjunctivitis was diagnosed on the basis of symptoms of itching, redness, and seasonal variation together with conjunctival and limbal signs. Amblyopia was diagnosed as any diminution of vision VA <6/12 that cannot be explained with ocular media or visual pathway itself and two lines difference on Snellens chart between two eyes was considered. Diagnosis of vitamin A deficiency or Xerophthalmia was made if there was history of night blindness, or on examination, there were signs of conjunctival xerosis, bitot spots, corneal xerosis, or keratomalacia as per clinical grading by WHO.

Appropriate statistical tests were applied and P value < 0.05 was considered significant. For analysis, statistical software SPSS version 23 was utilized.

Results

A total of 13,492 students, (25.4% in government school and 74.6% in private school) of age group 6–16 years studying in standard I–XII were evaluated. There were 6,750 males and 6,742 females in study population. The students were divided into two broad age groups; Group 1 (6–10 years) of 5466 (40.5%) students and Group 2 (11–16 years) of 8026 (59.5%) students. The mean age of the students was 10.9 ± 2.7 years [Table 1].

Table 1
Table 1:
Summary of basic demographic details

In the study population, the overall prevalence of ocular morbidity of any form in either eye among children of age group 6–16 years was 23.2%. The estimated prevalence of ocular morbidities in private school was 24.4%, which was significantly (Statistical P value <0.001) higher than in government schools (19.6%). The overall prevalence of ocular morbidity was found to be more among males (24.1%) as compared to females (22.3%) with significant P value = 0.011. Both age groups (i.e. 6–10 and 11–16 years) had almost similar prevalence of ocular morbidity of any kind. There was no statistically significant relationship found between the prevalence of ocular morbidity and the age group or the class/standard of a student (P value > 0.05) [Table 2].

Table 2
Table 2:
Association between any ocular morbidity and demographic variables

The most common cause of ocular morbidity found was refractive error (18.5%), followed by color blindness (2.2%). The prevalence of total ocular disorders that were existent among study population is depicted in Fig. 1.

Figure 1
Figure 1:
Summary of prevalence of ocular morbidities

On individual disease comparison, refractive error constitutes the predominant cause of ocular morbidity seen in 1240 (18.4%) males and 1262 (18.7%) females. However, this difference was statistically insignificant with P value >0.05 and OR = 0.98 (0.9–1.07) with 95% CI. Various types of refractive errors were not subanalyzed further. Refractive error was present more in students studying in private schools (19.0%) as compared to those in government schools (17.2%). This difference was statistically significant with P value <0.05 and OR = 1.13 (1.02–1.26) with 95% CI [Table 3].

Table 3
Table 3:
Association between refractive errors and demographic parameters

On comparing the prevalence of individual ocular morbidity with gender distribution, a statistically significant difference was noted for color blindness (P < 0.001, OR = 2.26 with 95% CI 2.886–5.306), stye (P = 0.029, OR = 1.84 with 95% CI 1.054–-3.227), and nystagmus (P = 0.008, OR = 2.29 with 95% CI 1.22–4.293) with increased prevalence of ocular morbidity among males as compared to females. The rest of the ocular morbidities’ prevalence did not vary significantly with gender [Table 4].

Table 4
Table 4:
Association between the gender and prevalence of different types of ocular morbidities

Similarly, Table 5 shows the prevalence of ocular morbidities that were found to be more in private school as compared to government schools with statistically significant values (P < 0.05).

Table 5
Table 5:
Association between the type of school and prevalence of different types of ocular morbidities

The occurrence of stye (P value = 0.048, OR = 1.71 with 95% CI 0.9988–2.918), nystagmus (P value < 0.001, OR = 2.76 with 95% CI 1.505–5.073), allergic conjunctivitis (P value = 0.016, OR = 1.59 with 95% CI 1.087–2.319), and ptosis (P value = 0.044, OR = 1.93 with 95% CI 1.007–3.703) were observed more in children in the age group 6–10 years when compared to the age group 11–16 years, with statistically significant difference (P < 0.05). All other ocular morbidities were also compared, but differences were statistically insignificant [Table 6].

Table 6
Table 6:
Association between the age group and prevalence of different types of ocular morbidities

The prevalence of color blindness was observed more among males (3.0%) as compared to females (1.4%) with P value < 0.001 and OR = 2.26 (1.77–2.9) with 95% CI [Table 7]. It was also higher among students studying in private school (2.4%) against those in government schools (1.7%) with P value = 0.019 and OR = 1.41 (1.06–1.89) with 95% CI. Also, the students with color blindness presented with statistically significant more complaints related to eye disorders like refractive error (P value = 0.004, OR = 1.47 with 95% CI), chalazion (P- value <0.001, OR = 59.29 with 95% CI), and allergic conjunctivitis (P value <0.001, OR = 6.89 with 95% CI) [Table 7].

Table 7
Table 7:
Association between color blindness and all parameters

Discussion

This study screens 13492 students in order to gather data on current prevalence of various ocular morbidities among school-going children in the age group of 6–16 years.

The estimated prevalence of ocular morbidity in the present study was found to be 23.2%. The reported prevalence of ocular morbidities is variable among different geographical regions of study, which may be due to difference in race or ethnicity, age group studied, sample size, and methodologies adopted for screening, lifestyle, and living condition of population under consideration. The results of our study were almost comparable with another population-based study involving a similar age group conducted by Gupta et al.[6] in region of North India, who reported a slightly higher 31.6% prevalence of ocular morbidity. Possible reason for this was the significant contribution of refractive errors (22%) toward prevalence of ocular morbidity in their study. Both our study and by Gupta et al.,[6] reported nearly similar prevalence of color blindness (2.2 and 2.3%, respectively) in the study population. The studies from different regions of India, conducted by Agrawal et al.,[9] and Hashmi et al.,[10] also reported similar prevalence of ocular morbidities comparable with our results. However, both the studies reported lower prevalence of refractive error (5.2 and 13.19%, respectively) in comparison to our study. A study by Sarkar et al.,[11] conducted in city of Shillong (Eastern part of India) reported higher prevalence of ocular morbidity (76.3%) with refractive error as predominant cause (57.4%). Most of the studies conducted in various regions of India found refractive error as most common cause of ocular morbidity, which is in concurrence with our study [Table 8]. In our study, there was slight increase in prevalence of ocular morbidity in the older age group (11–16 years) compared to the younger age group (6–10 years). However, difference was statistically insignificant (P value > 0.05) [Table 2]. The similar trend was also observed in a study conducted by Singh et al.[5] The possible reason could have been that the children of older age group had more exposure to environmental insults and were more aware of their ocular problems in comparison with younger children. We also found that the students studying in private schools had higher prevalence (24.4%) of ocular morbidities as compared to those in government schools (19.6%). This can possibly be due to the fact that better socioeconomic strata in the former made them accessible to more use of mobile phone gadgets and second the large sample size in this group [Table 2]. However, a study by Gupta et al.[6] reported almost comparable prevalence of ocular morbidity among both government and private public schools, which is in contrast to our study.

Table 8
Table 8:
Comparison of prevalence of any ocular morbidity, refractive error, and color blindness from representative population of different regions of India

In the current study, the prevalence of color blindness was reported to be 2.2% with males affected predominantly. Agrawal et al.[13] and Mahajan and Gogna reported similar male preponderance of color blindness. This could be explained by the genetic fact that hereditary transmission of color blindness is X-linked recessive, where males are affected and females are usually carriers.

Our study showed the prevalence of corneal opacity in study population to be 0.1%, which was similar to those reported by Bigyabati et al.[14]

The prevalence of vitamin A deficiency was found to be 0.4%, which was much lower as reported by Agrawal et al. (9–11.1%)[9] due to urban setting and improvement in immunization coverage nowadays. Such high prevalence of vitamin A deficiency reported by Agrawal et al.[9] could be explained by data from national family health survey-3, which showed that state Chhattisgarh was among the last three states who missed opportunities for vitamin A supplementation in almost 80% cases.[15]

In our current study, the prevalence of strabismus was found to be 0.6%, which is lesser than reported in the study by Sarkar et al.[11] Our study reported allergic conjunctivitis as an important type of conjunctivitis with estimated prevalence of 0.8%, which was in accordance with the results reported by the International Study of Asthma and Allergies in Childhood (0.8–14.9%).[16]

Limitation of study

As our study was an urban setting-based screening study; hence, results may not be comparable to the rural setting-based school study. Also, due to time constraint and logistical issues, we could not be able to analyze refractive errors into further subtypes. There is gross difference in the sample size between Government and private schools. Testing of color vision by Ishihara chart can miss detection of milder version.

Conclusion

The results of such a large-scale school-based eye screening study may reflect the current true prevalence of ocular morbidities among school-going children in the region of North India. Refractive error was found to be the most common ocular morbidity followed by color blindness. Hence, data from this study could be utilized in devising and implementation of cost effective, school level, health facility-based appropriate eye care strategies targeting the school-going age group to reduce burden of visual impairment among vulnerable population in the country, especially in Northern India.

Financial support and sponsorship

This manuscript is result of Extramural research project with financial grant and by Uttarakhand State Council for Science and Technology, Dehradun.

Conflicts of interest

There are no conflicts of interest.

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    Keywords:

    Childhood ocular morbidity; color blindness; prevalence; refractive error; school eye screening

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