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Original Article

Subjective outcome and quality of life following external dacryocystorhinostomy

Dani, Koshal; Yadalla, Dayakar1; Joy, Anupama1; Wu, Annie M2; R, Jayagayathri1,

Author Information
Indian Journal of Ophthalmology: July 2021 - Volume 69 - Issue 7 - p 1882-1886
doi: 10.4103/ijo.IJO_3043_20

Abstract

Nasolacrimal duct obstruction (NLDO) is one of the commonly encountered problems in ophthalmic clinical visits.[1] NLDO leads to stasis and secondary infection which can present as acute and chronic dacryocystitis with epiphora and purulent discharge. Complete obstruction of nasolacrimal duct is usually treated by dacryocystorhinostomy (DCR) surgery.[2] NLDO and chronic dacryocystitis are also risk factors for endophthalmitis after intraocular surgery.[34] And so any intraocular surgery should be delayed until obstruction is removed by DCR surgery. However, no disease-specific tools to assess the symptoms and the subjective outcome after DCR have been established. The purpose of this study is to assess the patient reported outcome and quality of life in post external dacryocystorhinostomy operated patients.

Methods

This prospective study included 112 patients who had undergone external dacryocystorhinostomy over a period of 1 year in our tertiary eye centre. A pre validated questionnaire – the Glasgow benefitary inventory (GBI) questionnaire [Supplementary Fig. 1] was given to the patients who volunteered for the study, all the patients included in the study consented for the study. The questions are specifically tailored to measure a change in health status, defined as the general perception of well-being (12 questions). Social and physical health parameters are also assessed, with three questions each. The total GBI scores from − 100 (maximal negative benefit), through zero (no change) to + 100 (maximal positive benefit in health status). Dacryocystorhinostomy surgery was performed for all cases with nasolacrimal duct obstruction by one of the two surgeons in Orbit and Oculoplasty clinic in our hospital.

The inclusion criteria included 1. Patient diagnosed with Chronic dacryocystitis. 2. All those patients who are successfully operated with external dacryocystorhinostomy. The exclusion criteria were: 1. Patients with congenital nasolacrimal duct obstruction. 2. All failed operated cases of chronic dacryocystitis. 3. Patients with primary hyper lacrimation- like tear film and ocular surface disorders, lacrimal gland tumours and cyst, effect of strong parasympathomimetic drugs are excluded. 4. Patients with other causes of reflex hyper lacrimation and central lacrimation are also excluded.

All the subjects who underwent successful dacryocystorhinostomy surgery were called for postoperative follow-up examination on postoperative month1 and 3 and were asked to answer the questionnaire as per their response to the surgery. Vision, intraocular pressure, slit lamp biomicroscopy to examine tear film and swelling around the sac was done on both the visits and they were asked about any symptoms of pain and swelling around the sac area both the times. The study adhered to the tenets of the Declaration of Helsinki and was approved by the institutional Review Board and the Ethics committee of the institute. No waivers were granted.

Results

Our study included 112 eyes of cases of Nasolacrimal duct obstruction who fulfilled the inclusion criteria. Various demographic factors were studied, such as age, sex, and laterality. All baseline clinical evaluation for nasolacrimal duct obstruction were done as described previously. All cases underwent DCR surgery and the surgical outcome was studied. Cases were followed up for 1 and 3 months respectively and subjective outcome along with questionnaire to assess the quality of life outcome was assessed. The clinical examination of the patient included the presence or absence of tearing and the presence of pain and swelling around sac area at baseline and at postoperative 1 and 3 months. Mean (SD) of the age was 48.03 (12.79) years and it ranged from 7 to 72 years as compared to Speillmann PM et al.[5] where mean age is 59 years. Among the total 112 study cases, 44 (39.3%) patients were males and 68 (60.7%) patients were females [Table 1]. In our study, the incidence of nasolacrimal duct obstruction was found to be almost same on right (52.7%) and left side (47.3%), there was no side predilection. Wilcoxon sign rank test was used to find out the significant difference in BCVA at baseline and post-operatively. P value less than 0.05 was considered as statistically significant. The P value shows that there was a significant difference at baseline and month1 (p-value = 0.025), month3 (p-value < 0.001) BCVA [Table 2]. Paired t-test was used to find out the significant difference between baseline and post-operative IOP. The P value (>0.05) showed there was no significant difference at baseline and month1 (p-value = 0.702), month3 (p-value = 0.400) IOP. Paired t-test was used for assessment of patient quality of life outcome for all the questions and was found clinically significant (p value < 0.05) for most of the answers as described in the table. [Table 3] Wilcoxon sign rank test was used to find out the significant difference between month1 and month3 GBI score (Total, General, Social and Physical). The P value showed a significant difference in the total score (p-value < 0.001), general score (p-value < 0.001), social support score (p-value = 0.0001) and physical health (p-value < 0.001) at month1 and 3 [Table 4].

T1
Table 1:
Best corrected visual acuity in cases of study group at baseline and post operatively
T2
Table 2:
Intraocular pressure at baseline and post operatively in cases of study group
T3
Table 3:
Assessment of GBI questionnaire post operatively at 1 and 3
T4
Table 4:
GBI score analysis for all four parameters of GBI questionnaire

Discussion

Epiphora, defined as overflow of tears from the eye, can have a significant impact on QoL, causing discomfort, embarrassment, and blurring of vision. Kafil-Hussain et al.[6] found that patients with epiphora suffer greater visual handicap in multiple areas of activities of daily living compared with the patients awaiting a second cataract surgery. Therefore, improving patient’s QoL and symptoms are key objectives for surgery to treat epiphora. The incidence of nasolacrimal pathway obstruction increases with age, and dacryocystorhinostomy (DCR) is a commonly applied surgical technique to treat such cases. However, no disease-specific tools to assess the symptoms and the subjective outcome after DCR have been established. The Glasgow Benefit Inventory (GBI) which is a validated, generic patient-recorded outcome measure widely used in otolaryngology to report change in quality of life post-intervention, in a prospective clinical trial.[7] Currently, questionnaire-based patient-reported outcome measures for procedures for epiphora are limited to DCR surgery. Several studies have assessed patient benefit following DCR surgery using the generic GBI questionnaire, which has been validated for DCR surgery and shown to be sensitive to change following an intervention.[8] GBI is not procedure-specific and therefore also permits comparison across different in terventions, and can differentiate between successful and unsuccessful procedures.[9] Other methods of measuring QOL are Single-item symptom scores, single-item reports of improvement, Lacrimal Symptom Questionnaire (0.5%), Nasolacrimal Duct Obstruction Symptom Score, Ocular Surface Disease Index, Visual Function Questionnaire, the Short Form-36 Health Survey[10] and Lac-Q questionnaire[11]

Each year, 1.6-1.9 million cataract operations are performed throughout India, many in “camps” or rural peripheral centres where preoperative syringing of the nasolacrimal system is routinely performed prior to cataract surgery[12]; the aim is to exclude NLDO, a major risk factor for postoperative endophthalmitis. Panophthalmitis can occur if any intraocular operation is undertaken due to unrecognized dacryocystitis. Knowledge about the subjective outcome including tearing, pain and swelling around sac area and whether there is overall quality of life improvement following external dacryocystorhinostomy can significantly influence the choice of surgery following nasolacrimal duct obstruction and patient quality of life in general.

Among the total 112 study cases, 44 (39.3%) patients were males and 68 (60.7%) patients were females. Females showed a higher incidence of 60.7% in our study as compared to males (39.3%). Hartikainen et al. also found a female to male ratio of 79%:21%.[13] and Badhu et al. reported, incidence in females to be 67.6%[14] as compared to males.

In our study, incidence of nasolacrimal duct obstruction was almost the same on right side with 59 eyes (52.7%) and left side with 53 eyes (47.3%). Ghose et al.[15] and Brook et al.[16] found that there was a relatively high incidence of the disease on the left side as compared with that on the right side. In general, the disease had a predilection to the left side as the nasolacrimal duct and the lacrimal fossa formed a greater angle on the right side than on the left side.[17] No such side predilection was found in our study and is almost same on both the sides.

There is significant improvement in symptoms of the patients in our study with almost no patient complained of epiphora at 1 and 3 months postsurgery (only successful cases were selected for the study) and also very few patients -40 patients (45.9%) complained of mild (38 patients-95% patients had only mild pain and swelling) to moderate (2 patients -5%) pain and swelling at 1 postoperative visit as compared to 87 patients (87.7%) preoperatively who had mild to moderate pain and swelling at sac area and none of the patients had pain and swelling around the sac area at 3 months following external dacryocystorhinostomy, which suggests a better subjective outcome of the patients on long run after the surgery. There was significant improvement in mean BCVA post operatively (p value of 0.025 and < 0.001 at 1 and 3 months respectively) similar to SHIN JH et al.[18] Improvement in visual acuity in the setting of decreased epiphora may be attributed to less blurring of images, as has been previously observed.[19] There was no significant difference in intraocular pressure post operatively; intraocular pressure would not have been expected to change after DCR.

Our study aimed at four parameters from the GBI questionnaire: total GBI score, general subscale, social and physical outcome of the patient at 1 and 3 respectively. The mean total score of 32.22 and 48.86 at 1 and 3 month [Fig. 1a] are clinically significant and suggests improvement in overall quality of life in patients postsurgery which are better as compared to other study groups as the total GBI scores were +42.67 (95% CI: 33.42–51.91) for DCR in study by Z Sipkova et al.[20] and similar to Speillmann PM et al.[5] where mean overall GBI was + 32.7. The general subscale score (mean of 31.21 and 44.08 at 1 and 3 months respectively) [Fig. 1b], with P value of P < 0.001 suggest the general subscale score is statistically significant ,thus there is significant improvement in routine general overall life style where patient feels more optimistic about his future, is less embarrassed with group of people, more confident doing routine activities of the patient, finds more support from his friends, more confident about finding job opportunities and finds himself much comfortable in the society. The social health score (mean of 46.28 and 61.01 at 1 and 3 months respectively) [Fig. 1c] were also statistically significant with P value of P < 0.001 indicating improvement in social health of the patient postoperatively like getting more of support from family and friends. The physical health score (mean of 22.17 and 55.80 at 1 and 3 months respectively) [Fig. 1d] and P value of 0.0001 is statistically significant and suggest that there is considerable improvement in the physical health in terms of now patient has to less often visit his general physician for other reasons like colds, fever and other infectious diseases. All the four parameters under study: total GBI score, general subscale, social and physical outcome of the patient at 1 and 3 months showed statistical significance and hence the result can be drawn that the questionnaire very well highlights the improvement in quality of life of patients who underwent external dacryocystorhinostomy.

F1
Figure 1:
(a): Comparison of average total GBI score at month1 and 3. (b) Comparison of average general subscale score at 1 and 3. (c) Comparison of average social support score at 1 and 3. (d) Comparison of average physical health score at 1 and 3

Strength

Strong inclusion and exclusion criteria to study the subjective outcome and quality of life outcome post external dacryocystorhinostomy considered in the aim of the study. The sample size of 112 eyes with strict inclusion and exclusion criteria was modest compared to previous studies- M.Feretis et al.[7] -64 patients. In literature there are limited studies about subjective outcome and quality of life assessment using a pre validated questionnaire in cases of chronic dacryocystitis operated by external dacryocystorhinostomy only. There are many studies comparing endonasal DCR and external DCR like Bakri SJ et al.[21] with similar benefits and Javed Ali M et al.[22] comparing external DCR and transcanalicular DCR, whereas Ali MJ et al.[11] has studied outcomes of powered endoscopic DCR in adults using Lac-Q questionnaire. As there is paucity in Indian literature, regarding data on the subjective outcome and quality of life assessment after external-DCR in the South Indian population, this study contributes to it.

Limitations

The type of study is a prospective questionnaire based non randomised study including only one questionnaire. Duration of follow up cases: 1 and 3 follow ups could have been extended to 6 and 12 months but was not possible due to time restraint. Age wise distribution of the patient to study the outcome in specific group of patients was not done in the study. Childhood NLDO was excluded as compared to study by Holmes JM et al.[23] which studied childhood NLDO.

Conclusion

This study suggest that cases of chronic dacryocystitis operated by external dacryocystorhinostomy can significantly improve the subjective outcome of the patient in terms of decreased to nil tearing and relief from symptoms of pain and swelling around the sac area over a period of 1-3 months after the successful surgery in these patients. The assessment of quality of life outcome based on parameters of overall improvement in quality of life, physical and social health improvement by using the Glasgow benefit inventory- GBI questionnaire can be very well established from this study and is an effective tool in assessing the quality of life outcome following external dacryocystorhinostomy. Our study proves that external dacryocystorhinostomy - considered as the gold standard procedure is still an effective tool to bring a clinically significant change in subjective and quality of life outcome in a large number of patients in a tertiary eye care centre.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

Supplementary Figure 1

The GBI questionnaire

References

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Keywords:

Chronic dacryocystitis; external dacryocystorhinostomy; Glasgow benefit inventory (GBI); quality of life; subjective outcome

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