Optic nerve germinomas can be misdiagnosed as optic neuritis. Herein, we report a child suspected to have bilateral optic nerve inflammation but subsequently diagnosed as infiltrative optic neuropathy.
An eleven-year-old child presented with complaints of sudden onset painless vision loss in both eyes over 6-week duration. She was suspected to habe bilateral retrobulbar optic neuritis and treated with intravenous methylprednisolone therapy for 3 days followed by oral steroids taper 3 weeks back elsewhere. She had undergone complete serological work up-hemogram, NMOIgG Ab, Quantiferon TB, VDRL, RA, ANA, ANCA, ACE, lysozyme, and Mantoux skin test, which were all negative prior. On examination, her best corrected visual acuity was 1/60, less than N 36 in right eye, and 6/18, N6 in left eye. Both pupils reacted sluggishly to light with relative afferent pupillary defect in the right eye. Color vision was reduced in both eyes. Fundus examination revealed pale disc in both eyes. Humphrey visual field with size 5 target of both eyes revealed advanced field loss right more than left eye. Visual evoked potentials of both eyes showed a delayed latency and reduced amplitude more in the right than the left eye. Magnetic resonance imaging (MRI) brain and orbit with gadolinium contrast revealed thickened right optic nerve and bulky chiasm with postcontrast enhancement [Fig. 1]. While the patient was on tapering oral steroids, she had developed skin lesions due to varicella zoster infection. Cerebrospinal fluid examination did not show any abnormal cells. She was treated with IV immunoglobulin and acyclovir. On her 2-month follow-up, her visual acuity further dropped to perception of light in right eye and 1/60 in left eye. Apart from a history of polyuria and polydipsia, her referral neurological examination was normal. Repeat lumbar puncture revealed increased CSF protein. By then her vision had dropped to no perception of light in both eyes. She was suspected to have progressive demyelinating disorder – NMOSD – ON (Neuromyelitis optica spectrum disorder associated optic neuritis) and received a course of intravenous methylpredninsolone therapy and a dose of intravenous rituximab 500 mg. However, her serum NMO IgG antibody was negative, her brain and spine MRI did not reveal any demyelinating lesions. But, repeat MRI brain and orbits revealed increase in size and thickening of bilateral optic nerves and chiasm with contrast enhancement when compared with previous imaging [Fig. 2]. As she had progressive optic neuropathy with no response to therapy and increase in optic nerve and chiasm thickening, optic nerve biopsy was done. Biopsy revealed a poorly differentiated malignant tumor, probably germinoma [Fig. 3]. She was advised for radiotherapy and her polyuria and polydipsia improved following oral desmopressin.
Intracranial germ cell tumors affect children and young adults, with peak incidence of 10–19 years of age. Clinical manifestation depends on the location and size of the tumor and associated endocrine abnormalities. Visual pathway germinomas involving chiasm and optic nerve are rarely reported. Clinical and radiological features of intracranial neoplasm can mimic granulomatous inflammation making early diagnosis difficult. Strong inflammatory reaction can accompany germinomas. Suprasellar germinomas often present with diabetes insipidus followed by visual impairment. Infundibular thickening is usually observed as a feature of neurohypophysis germinomas. Due to anatomic proximity of neurohypophysis and optic chiasm, progressive visual decline can occur due to compression, tumor cell invasion, and the associated inflammation. Poor visual recovery following steroid therapy with clinical features of presumed optic neuritis and thickened optic nerve and chiasm on neuroimaging can be seen in granulomatous diseases and NMO-SD associated optic neuropathies. Germinomas are radiologically well delineated, oval or lobular or partly infiltrative, and expansive tumors. Differential diagnosis of bulky chiasm includes inflammation (infundibuloneurohypophysitis, Wegener's, sarcoidosis), neoplasm's (langerhans cell histiocytosis, metastases, brain tumors, leukemia's), or infections (tuberculosis).
Krolak-Salmon et al. reported a patient with similar presentation who was treated as having optic neuritis with high-dose corticosteroids.
This case report emphasizes that infiltrative optic neuropathy in a child can be misdiagnosed as demyelinating disorder, but repeated neuroimaging and biopsy are required to clinch the diagnosis. In this case, germinoma masqueraded as inflammatory optic neuropathy.
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