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Letters to the Editor

Congenital nasolacrimal duct obstruction

Should we continue lacrimal massage till 1 year or perform an office probing at 6 months? A clinical decision analysis approach

Kothari, Mihir1,2,; Rathod, Vivek1; Shah, Kruti1; Shikhangi, Khushboo1; Singhania, Renu1

Author Information
Indian Journal of Ophthalmology: February 2017 - Volume 65 - Issue 2 - p 167-169
doi: 10.4103/ijo.IJO_245_16
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Sir,

We read the study by Bhandari et al.[1] with interest. It was of particular interest to us because probing for the congenital nasolacrimal duct obstruction (CNLDO) remains the second most common ocular surgical intervention in pediatric ophthalmology clinics and it is of interest to all the ophthalmologists and pediatricians. The CNLDO affects as many as 20% children aged <1 year worldwide.[2]

A failure rate of 70% with lacrimal massage as reported by the authors[1] and the increase in the failure rate of probing by 25% for every 6 months delay bring us to a question whether is it better to wait for probing for approximately a year or year and a half (as practiced today) or perform a probing early at 6 months age. Other disadvantages of delaying the probing could be more medical visits, longer duration of persistent symptoms, and a compulsion to give general anesthesia if probing is needed later. The idea of performing an “office probing” is especially attractive when we consider the reported success rate of 75% by the Pediatric Eye Disease Investigator Group (PEDIG)[3] and the ease with which it can be performed by restraining the child without the need of general anesthesia. Moreover, a failed office probing would not increase the failure rate of repeat probing later if the need be.[3]

To answer the question whether we should advise an early office probing (at 6–9 months) versus a delayed conventional probing (at 12–15 months) in children with CNLDO, we reviewed the study published by the authors,[1] compared similar data from our center and used the data from the study on office probing published by PEDIG [Table 1] using a clinical decision analysis approach that was previously published in this journal.[4]

Table 1
Table 1:
Summary of the results of the three studies reporting the treatment of congenital nasolacrimal duct obstruction

The reason we had to separately create the decision tree using our (urban) data was because our patients were from higher socioeconomic strata and presented at an earlier age in contrast to that in the study by Bhandari et al.[1] The physical health of the patients from different socioeconomic strata could affect their respiratory status and the compliance to treatment and a late age of presentation also negatively affects the outcome of the treatment of the CNLDO.

When we applied the decision analysis approach to the study data of patients from lower socioeconomic strata and rural area [Fig. 1][1] as well as those from the higher socioeconomic strata and urban area [Fig. 2], we found that office probing was an unequivocal winner in both the situations. The decision tree for each group was created using the steps mentioned below:

Figure 1
Figure 1:
Decision analysis tree for lower socioeconomic set up (Bhandari et al.)
Figure 2
Figure 2:
Decision analysis tree for higher socioeconomic set up (from urban area)
  1. The disease in question was CNLDO in children
  2. The possible actions of a clinician would be either to advice lacrimal massage or advice an office probing
  3. The potential outcomes/events would be (1) success (resolution of the disease) or (2) failure to resolve or (3) a complication during waiting period after advising massage or due to the office probing
  4. The payoffs as decided by the authors of the current paper were:
    1. Best payoff was success with any modality of the treatment. The payoff value assigned was 1
    2. Worst payoff for the outcome of any given treatment modality was 0 if there was a complication
    3. Failure with massage was considered to have higher payoff value of 0.5 versus 0.25 for office probing. The authors of this paper felt that failed massage had higher morbidity due to a prolonged duration of the disease, repeated medical visits associated with the same, and repeated use of topical antibiotics versus failed office probing that had no other complications.
  5. The outcome probability (from 0 to 1) and rank (from 0 to 1) were multiplied to calculate final weightage for each outcome
  6. A total score for each action of the clinician was calculated. The action that lead to the higher score was considered the winning decision.

Since the paper by Bhandari et al.[1] did not provide data regarding the complications (viz. acute dacryocystitis, lacrimal abscess, orbital cellulitis, and lacrimal fistula) suffered by the group that was advised to perform lacrimal massage while they were waiting for an eventual probing/resolution, we used the data from our study to construct the decision trees. In our study, we had found a compliance rate of 78% for the Criggler's technique of massage (10 strokes given three times/day).

We thank and congratulate Bhandari et al.[1] for publishing their data in the Indian journal of ophthalmology. It has helped us break away from the “tradition” of performing late probing in favor of an early office probing (i.e., probing at 6 months of age by restraining the child as defined by PEDIG), at least in high-risk cases, based on the science of decision analysis.

Nevertheless, despite of a decision analysis many ophthalmologists including us do not feel confident adopting it as a preferred practice pattern due to three factors. (1) Lack of randomized controlled trial demonstrating clear advantage in doing early probing, (2) lack of popularity of office probing in our country, and (3) presumed difficulty in performing probing without the anesthesia in young babies.

Nevertheless, it may be prudent to offer office probing to the parents of children suffering with bilateral CNLDO where the success rate of lacrimal massage is poor[13] or in children with recurrent episodes of acute pericystitis. If the ophthalmologist has an apprehension regarding performing the probing without anesthesia, a short inhalational anesthesia such as sevoflurane or isoflurane with topical proparacaine hydrochloride can be used for an office probing.

So far, we have done six office probings, of which one had failed. The mother reported that the child had a repeat probing by another ophthalmologist under general anesthesia at an older age which was successful! The office probing performed by us included the standard protocol [Table 2 and Fig. 3] and was not different from the late/conventional probing performed under general anesthesia barring, a nasal endoscopy and the fluid irrigation (syringing), which was not done in office probing.

Table 2
Table 2:
Protocol of office probing
Figure 3
Figure 3:
Photograph showing the technique of office probing in a young child. (a) Child with encysted nonresolving dacryocele, (b) 0000 number Bowman probe is held at 30 mm, (c) 30 mm probe inserted in nasolacrimal canal

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

Acknowledgment

  1. Dr. Ravi Thomas, for his relentless efforts to teach us the science of ophthalmology including the decision analysis approach
  2. Ms. Maahi Mihir Kothari for her help with data entry.

References

1. Bhandari S, Sengupta S, Yadalla D, Rajagopalan J, Velis GB, Talele D, et al Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India Indian J Ophthalmol. 2015;63:759–62
2. MacEwen CJ, Young JD. Epiphora during the first year of life Eye (Lond). 1991;5:596–600
3. Miller AM, Chandler DL, Repka MX, Hoover DL, Lee KA, Melia M, et al Office probing for treatment of nasolacrimal duct obstruction in infants J AAPOS. 2014;18:26–30
4. Korah S, Thomas R, Muliyil J. An introduction to clinical decision analysis in ophthalmology Indian J Ophthalmol. 1999;47:41–8
© 2017 Indian Journal of Ophthalmology | Published by Wolters Kluwer – Medknow