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Original Article

Risk factors for intraocular pressure rise following phacoemulsification

Coban-Karatas, Muge; Sizmaz, Selcuk; Altan-Yaycioglu, Rana; Canan, Handan; Akova, Yonca Aydin

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Indian Journal of Ophthalmology: March 2013 - Volume 61 - Issue 3 - p 115-118
doi: 10.4103/0301-4738.99997
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Intraocular pressure (IOP) may rise even after uncomplicated cataract surgery which might need intervention.[12] The response in IOP to phacoemulsification is biphasic, with a transient immediate rise followed by a modest long-term decrease.[35] Postoperative IOP usually peaks 5–7 h after surgery and returns to normal levels in 1–3 days.[367] Although transient, the elevated IOP can cause ocular pain, may increase the risk of sight threatening complications such as retinal vascular occlusion, progressive field loss in advanced glaucoma, and anterior ischemic optic neuropathy in susceptible patients.[89] Several risk factors such as glaucoma, viscoelastic agent, and surgical procedure for postoperative IOP rise have been identified.[310] Our aim in this study was to analyze the risk factors that might result in IOP rise following uneventful phacoemulsification.

Materials and Methods

We retrospectively evaluated the records of 812 eyes of 584 consecutive patients, who underwent uncomplicated clear corneal incision phacoemulsification surgery in our clinic between May 2004 and July 2008. There were 330 men and 254 women ranging between the age of 26 and 89 years (65.4 ± 9.8 years).

All the surgical procedures were performed by two surgeons (RAY and SS). All the patients had peribulbar anesthesia and uncomplicated phacoemulsification surgery via 2.85 mm corneal incision placed either temporal, or oblique. Two side port incisions were made to allow access of a second instrument. Dispersive viscoelastic (Viscoat, Alcon, TX, USA) was used to fill the anterior chamber. Continuous curvilinear capsulorhexis was performed routinely. In mature cataracts before performing capsulorhexis, trypan blue was used to dye the capsule. During phacoemulsification, a stop and chop or phaco-chop technique was used. Following, the corneal incision was enlarged to 4.0 mm. The capsule was filled with a cohesive viscoelastic (Provisc, Alcon, TX, USA), and a foldable posterior chamber intraocular lens was implanted in the capsular bag. Viscoelastic was thoroughly removed via bimanual irrigation/aspiration (I/A), and a rock and roll technique was used for the removal of viscolelastic behind the IOL.

The preoperative as well as postoperative first day, first week, and first month visit IOP values were measured by non-contact tonometer (Full Auto Tonometer TX-F, Canon Inc, USA) and recorded. IOP was grouped as normal (≤22 mmHg) and high (≥22 mmHg). All the glaucoma patients were primary open angle glaucoma. Patients that suffer from other types of glaucoma were excluded from the study. Patients who were receiving antiglaucomatous medication also continued to receive the same medication before and after surgery. None of the patients was given prophylactic medication before the surgery. Antiglaucoma drugs that incite more inflammation like prostaglandin analogs were stopped 2 weeks before surgery and an antiglaucoma drop that does not incite inflammation was prescribed. Antiglaucoma drugs that incite more inflammation like prostaglandin analogs were stopped 2 weeks before surgery. An antiglaucoma drug that does not incite inflammation was prescribed and continued for 1 month after surgery. In addition, acetazolamide was not given after the surgery.

All data were entered to SPSS software (Statistical Package for the Social Sciences, version 10.0, SPSS Inc, Chicago, IL, USA) and the changes in IOP were compared with paired Student's t-test. Data on prior history of glaucoma, pseudoexfoliation (PXF), incision site, anterior capsular staining, and surgeon were recorded. The relation of these factors with postoperative high IOP at each visit (days 1, 7, and 30) were evaluated using multinomial regression analysis. The level of significance was set at <0.05.

This study was approved by Baskent University Institutional Review Board and Ethics Committee (project no: KA10/31).


The mean preoperative IOP was 15.6 ± 4.3 mmHg (ranged from 7 to 36 mmHg). At day 1, the IOP increased significantly to 19.7 ± 9.0 mmHg (ranged between 6 and 58 mmHg; P < 0.001, 95% CI −4.68 to −3.52). The mean IOP was 12.7 ± 4.5 mmHg (ranged between 6 and 37 mmHg) at day 7, and 12.8 ± 3.7 mmHg (ranged between 6 and 34) at day 30. Compared to the preoperative values, days 7 and 30 IOP values were significantly low (P < 0.001, 95% CI 2.54–3.17 for day 7, and 2.47–3.03 for day 30).

At day 1, the high IOP was detected in 249 (30.7%) eyes with a mean of 30.7 ± 7.5 mmHg. At day 7, the number of patients with high IOP decreased to 26 eyes (8.8%). Similarly, at day 30 only 16 (1.2%) eyes had the high IOP.

The incidences of high IOP with possible associated factors are shown on Table 1. Diabetes was present in 100 eyes (12.3%), PXF was observed in 77 eyes (9.5%), and glaucoma in 60 eyes (7.4%). In 477 eyes (58.7%), the operation was performed through a temporal incision, and in 335 eyes (41.3%) a superior oblique incision was performed. Trypan blue was used in 43 eyes (5.3%.).

Table 1
Table 1:
The distribution of IOP values as normal (≤22 mmHg) or high (>22 mmHg) at each visit (day 1, day 7, and day 30) according to the investigated factors such as surgeon, pseudoexfoliation (PXF), glaucoma, PXF and glaucoma, diabetes (DM), incision [so: Superior oblique, t: Temporal], trypan dye [1: Present; 2: Absent]

With the multinomial regression analysis, none of the factors was related to the high IOP postoperatively (P < 0.05), except glaucoma. Glaucoma was the only factor related to high IOP values during the postoperative period (P = 0.004 at day 1, 0.001 at day 7, and < 0.001 at day 30). Of the 60 glaucomatous eyes, all were receiving the glaucoma medication. The IOP was high in 30 eyes (51.7%) in the first day, in 7 eyes (12.1%) in the first week, and in 6 (10.3%) patients in the first month.


Transient IOP rise may be observed in the early postoperative period after uneventful cataract surgery.[1113] In this study, we retrospectively evaluated the risk factors that might affect the IOP rise following uncomplicated phacoemulsification surgery. The IOP measurements were recorded at the postoperative days 1, 7, and 30. We accepted 22 mmHg as the cut-off point for high IOP. Thirty percent of all eyes had high IOP at day 1. Among all the factors such as surgeon, diabetes, PXF, glaucoma, incision site, and trypan blue use, the only factor related to postoperative high IOP values was glaucoma (P ≤ 0.001).

Our results indicate that short-term postoperative IOP was higher in eyes with primary open angle glaucoma than in nonglaucomatous eyes (P ≤ 0.001). In another study, glaucoma was reported as a risk factor for pressure rise after phacoemulsification and the incidence of substantial elevation in IOP was similar between the eyes with primary open angle glaucoma and those with pseudoexfoliative glaucoma.[14] Tong and Miller[15] retrospectively investigated the preoperative and postoperative IOP measurements of 385 consecutive eyes having uneventful phacoemulsification. Patients with preoperative diagnosis of glaucoma had significantly higher IOP at postoperative first week. Yasutani et al.[14] also mentioned that a substantial increase in IOP occurred in approximately 13% of the eyes with open angle glaucoma 1 day after phacoemulsification surgery.

In our study, PXF with normal IOP was not significantly correlated with high IOP even in the early postoperative period after uneventful phacoemulsification. Also in two studies, it has been reported that there was no significant difference in the IOP after phacoemulsification in eyes with and without PXF.[1617] On the other hand, a long-term lasting reduction in mean IOP occurred in PXF eyes.[1821] Damji et al.[21] demonstrated that in the 2 year follow-up, the patients with PXF have a greater IOP lowering effect following phacoemulsification than those without, and the authors concluded that this effect was correlated with the volume of irrigating fluid utilized at the time of surgery. In addition to these results, Cimetta and Cimetta[18] operated a group of 39 open angle, nonglaucomatous eyes with cataract and PXF syndrome and a control group of open angle, nonglaucomatous eyes with cataract, using a standard phaco technique along with bimanual anterior capsule PXF material aspiration. Phacoemulsification with anterior capsule PXF material aspiration significantly reduced the mean diurnal IOP in the PXF group lasting one year postoperatively. In another retrospective comparative study, 1122 eyes with PXF, 240 with glaucoma and 882 without glaucoma underwent uneventful phacoemulsification. A long-term reduction in mean IOP occurred in PXF eyes with or without glaucoma.[19] However, IOP rise in the early postoperative period was noted after phacoemulsification in nonglaucomatous eyes with PXF and IOP control was advised.[2224] This early IOP rise may be due to severe inflammation after cataract surgery in eyes with PXF due to pathological iris vessels with an increased permeability for protein. In addition, there were eyes with an elevated IOP without inflammation in the PXF group in which the mechanism of IOP rise could not be identified.[23] However, in this study, with or without glaucoma, we did not observe any relation of PXF to high IOP.

Anterior capsular staining with trypan blue in our study was not associated with high IOP at any postoperative visit (P > 0.05). In a preliminary study, 25 eyes of 25 patients with a unilateral mature or hypermature cataract, trypan blue dye was used to stain the anterior capsule. Adverse reactions related to the dye such as raised IOP were not observed in the immediate postoperative period or at the end of the mean follow-up of 3 months.[25] In a comparative study, phacoemulsification of 82 patients who had white mature cataract in one eye and senile cataract in the other were operated. Trypan blue dye was used in the white mature cataract and not used in the fellow eye. Postoperative IOP was not significantly different in the two groups.[26] In a previous study,[15] wound construction, anesthesia type, the eye operated on, patient age, and sex did not significantly influence the postoperative pressure change. Similarly in this study, there was no correlation between history of diabetes, surgeon, and incision site (P > 0.05). Surgeon's experience was reported as an important factor for the postoperative IOP rise. The mean pressure rise in eyes operated by experienced surgeons was about half the pressure rise in eyes operated by beginners, as beginners often perform intraocular surgery in a more traumatizing manner than experienced surgeons.[6] In our study, there was no relation between high IOP and surgeon. This was most probably related to the similar experience of two surgeons in present series.

As for the incision site, a study that compares temporal sclerocorneal or clear corneal incision, postoperative IOP was significantly higher in the sclerocorneal tunnel group than in the clear corneal incision group.[27] In our group, all surgeries were performed via clear corneal incision, so we are unable to compare with different types of incision.

In conclusion, our study demonstrated that following uneventful phacoemulsification, the diagnosis of glaucoma was the only risk factor for IOP higher than 22 mmHg. On the other hand, according to our results, PXF was not a risk factor for high IOP. We believe that patients who have glaucoma are at risk, and should be monitored closely for high IOP following phacoemulsification surgery.

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        Presented in ASCRS Symposium on Cataract, IOL and Refractive Surgery April 3‐8, 2009

        Source of Support: Nil,

        Conflict of Interest: Nil.


        Intraocular pressure rise; phacoemulsification; risk factors

        © 2013 Indian Journal of Ophthalmology | Published by Wolters Kluwer – Medknow