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Symposium

Alternative therapy in glaucoma management

Is there any role?

Parikh, Rajul S1,2,3,; Parikh, Shefali R1,4

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doi: 10.4103/0301-4738.73679
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Abstract

Doctor, is there anything else that I can do, other than putting medicines regularly, to prevent my eyes from becoming blind due to glaucoma?

No doubt, every ophthalmologist must have faced this intricate question again and again. Patients often asks about availability of alternative and complementary therapy (ACT) for glaucoma (due to improvement in patient awareness and easy access to internet). Definitely, we do not have enough scientific data to answer them affirmatively, but if we ignore their question as scarce literature available on internet may mislead them.[1] ACT for glaucoma refers to the disease management strategies other than conventional therapy, that is, pharmaceutical, laser, or surgical treatment known to lower intraocular pressure (IOP). A survey in an urban area of United Kingdom reported use of ACT by 5% of the patients; 60% of these would use more than one option for glaucoma management.[1]

Weak evidence suggests that certain lifestyle activities may elevate IOP and thus could predispose to primary open-angle glaucoma (POAG) in subset of patients. Detailed history of personal habits and lifestyle has helped to solve some complicated progressive glaucoma patients with otherwise normal IOP on diurnal variation tests. A person playing high wind musical instruments (eg, Saxophone) can have two-fold increase in his IOP from baseline level for short duration.[2] Though there is no strong evidence that playing these instruments predisposes to glaucoma, it is reasonable to inform a glaucoma patient who play these instruments about this effect. Certain yoga exercises in inverted position (like Shirshasana) leads to two- to three-fold IOP rise from baseline for short duration.[3] We documented a three-fold increase in IOP during the inverted position (IOP checked with Tonopen?) in at least three of our progressive POAG patients with good 24-hour IOP control (personal communication with Dr. Rajul S Parikh). Though evidence is not sufficient to prove the role of inverted yoga exercises as a causal risk factor for glaucoma progression, it is imperative to inform glaucoma patients about IOP elevations associated with inverted posture.

A prolonged stress-induced increase in endogenous cortisol and catecholamines with subsequent alterations of the immune response may increase IOP.[45] So, it may be prudent to ask about potential psychosocial or environmental stress factors, especially in a patient who had stable disease and now has developed a dramatic rise in IOP or deterioration of visual function.

Caffeine is consumed by a high percentage of the general public. Most of the studies,[67] with some exceptions,[8] demonstrate 2 to 3 mm Hg increase in IOP that lasts for about 2 hours after use of coffee. However, coffee beans also contain compounds that have antioxidative effects.[910] These antioxidative effects and its possible neuroprotective implications need further research.

Literature also suggests the variable effect of alcohol on IOP and its role in neuroprotection. Weak evidence indicates that alcohol consumption leads to dose-related IOP reduction which may last for several hours through temporary osmotic effect.[1113] Intake of large quantities of beer or water definitely increases IOP significantly due to volume overload (mimicking water drinking test). However, a few other studies did not report any association between alcohol intake and IOP.[1415] ‘Neuro-protective’ effect of red wine has also been reported. Though consuming one alcoholic drink per day may have some cardiovascular benefits,[16] it also increases the risk of liver disease.[17] As evidence is not sufficient enough to prove the beneficial effects of alcohol on glaucoma, it is important to discourage the belief that drinking alcohol will reduce the risk of glaucoma. Moreover, we do not want people to initiate drinking at the age of 60 years to prevent ‘blindness’ and get cirrhosis. ‘Have Wine, keep your nerve healthy and prepare yourself for liver transplant.’

Similarly, literature showing the variable effect of exercise on IOP is available. Few studies reported that aerobic exercise causes lowering of IOP,[111820] while few other studies concluded that isometric exercise like lifting weights may produce a small IOP increase during exertion.[21] Certain subtypes of glaucoma like pigmentary glaucoma may have IOP rise after exercise. However, it remains uncertain whether such exercise-induced IOP changes correlates with glaucoma pathogenesis and/or progression. Currently, there are no cohort studies reporting the relationship between exercise and glaucoma; moderate aerobic exercise has many health benefits and thus should be encouraged.

Recently, there is a considerable interest in dietary antioxidants (e.g., red wine, dark chocolate, coca, green tea, curcumin, glutathione, n-6 to n-3 polyunsaturated fatty acid, etc) because oxidative stress may induce damage to the outflow channel as well as to the optic nerve.[22] However, there is no strong evidence suggestive of beneficial effect of dietary antioxidant intake and its neuroprotective effect on POAG;[23] further research is needed in this direction. At this time, one cannot promote antioxidant intake as a strategy to prevent the development of POAG or slow down its progression. Curcumin (used widely in India) having antioxidative property has shown possible beneficial effects on altering various mechanisms like oxidative stress, excitotoxicity, aberrant immunoregulation, neurotrophin deprivation, or abnormal TNF-α signaling.[24]

Marijuana, a cannabinoid, has been proposed as IOP-lowering agent for a long time. The active ingredient in marijuana (delta-9-tetrahydrocannabinoid) reduces IOP by reducing aqueous humor production.[2526] IOP-lowering effect of marijuana is for short term and one needs to smoke marijuana every 3 hours for 24-hour IOP control.[27] ‘Keep smoking, start hallucinating and keep your IOP under control.’ Fortunately, use of marijuana even for medicinal purposes is illegal in India. Overall, the existing evidence suggests that use of marijuana for glaucoma management is not a feasible option either for medical or legal reasons, as it may actually do more harm to other parts of the body. Recently, there is surge in interest in newer topical synthetic cannabinoid receptor agonist, WIN 55211-2 as it lowers IOP in rats, monkeys, and human beings with a tolerable side-effect profile.[28]

Gingko biloba and bilberry (shrubs that yield a fruit resembling blueberries) have been proposed as neuroprotectors. The main components of the Gingko leaf extract are flavonoid glycosides and terpene lactones. Gingko is thought to mediate its effects through several biological mechanisms including antiplatelet action, vasodilation, and antioxidant effect. There is little data regarding the effect of Gingko biloba on the course of glaucoma. A placebo-controlled randomized controlled trial (RCT) found that Gingko biloba improved preexisting visual field loss in some patients with normal tension glaucoma.[2930] Further research is mandatory before we start recommending use of ginkgo biloba along with conventional glaucoma therapy on a routine basis. Bilberry extracts contain high quantities of anthocyanin, a flavonoid with antioxidant properties. Various other herbs and plants have been proposed in various parts of the world and they are discussed in recent World Glaucoma Association Consensus book on medical management of open angle glaucoma.[30]

Acupuncture is also being used in different parts of the world as one of the alternative therapy for management of glaucoma. A Cochrane review in 2007 concluded that there is no useful data regarding the effect of acupuncture on glaucoma.[31] Patients should be counseled regarding the paucity of high-quality evidence on the beneficial effect of acupuncture in glaucoma and other diseases.

To conclude, when patients inquire about the relationship between lifestyle factors, alternative medicine, and glaucoma, the physician should take the opportunity to educate them about their disease. Few activities should be avoided by the glaucoma patients, although more evidence is needed to determine if these activities predispose to glaucoma or contribute to the progression of the pre-existing disease. There are no RCTs that assess whether ACT may prevent glaucoma or slow down the disease progression. When counseling patients about ACT, it is important to know which forms of therapy are not feasible or might be harmful. It is also important to emphasize that in current armamentarium of glaucoma management, ACT cannot substitute the conventional treatment available to lower IOP. We need to answer lots of questions before disregarding ‘alternative medicine’ or start using them along with our ‘standard care.’

1. Rhee DJ, Spaeth GL, Myers JS, Steinmann WC, Augsburger JJ, Shatz LJ, et al Prevalence of the use of complementary and alternative medicine for glaucoma Ophthalmology. 2002;109:438–43
2. Schuman JS, Massicotte EC, Connolly S, Hertzmark E, Mukherji B, Kunen MZ. Increased intraocular pressure and visual field defects in high resistance wind instrument players Ophthalmology. 2000;107:127–33
3. Baskaran M, Raman K, Ramani KK, Roy J, Vijaya L, Badrinath SS. Intraocular pressure changes and ocular biometry during sirsasana (headstand posture) in yoga practitioners Ophthalmology. 2006;13:1327–32
4. Garg SP, Dada T, Talwar D, Biswas NR. Endogenous cortisol profile in patients with central serous chorioretinopathy Br J Ophthalmol. 1997;81:962–4
5. Huschle OK, Jonas JB, Koniszewski G, Buchfelder M, Fahlbusch R. Glaucoma in central hypothalamic-hypophyseal Cushing syndrome Fortschr Ophthalmol. 1990;87:453–6
6. Ajayi OB, Ukwade MT. Caffeine and intraocular pressure in a Nigerian population J Glaucoma. 2001;10:25–31
7. Higginbotham EJ, Kilimanjaro HA, Wilensky JT, Batenhorst RL, Hermann D. The effect of caffeine on intraocular pressure in glaucoma patients Ophthalmology. 1989;96:624–6
8. Ricklefs G. Effect of caffeine containing tablets and Coca-Cola on the intraocular pressure of patients without glaucoma and patients with regulated glaucoma Klin Monatsbl Augenheilkd. 1969;154:546–51
9. Mozaffarieh M, Grieshaber MC, Orgül S, Flammer J. The potential value of natural antioxidative treatment in glaucoma Surv Ophthalmol. 2008;53:479–505
10. Wen X, Takenaka M, Murata M, Homma S. Antioxidative activity of a zinc-chelating substance in coffee Biosci Biotechnol Biochem. 2004;68:2313–8
11. Buckingham T, Young R. The rise and fall of intraocular pressure: The influence of physiological factors Ophthalmic Physiol. 1986;6:95–9
12. Houle RE, Grant WM. Alcohol, vasopressin, and intraocular pressure Invest Ophthalmol. 1967;6:145–54
    13. Harris A, Swartz D, Engen D, Beck D, Evans D, Caldemeyer K, et al Ocular hemodynamic effects of acute ethanol ingestion Ophthalmic Res. 1996;28:193–200
    14. Wilson MR, Hertzmark E, Walker AM, Childs-Shaw K, Epstein DL. A case-control study of risk factors in open angle glaucoma Arch Ophthalmol. 1987;105:1066–71
    15. Leske MC, Connell AM, Wu SY, Hyman LG, Schachat AP. Risk factors for open-angle glaucoma. The Barbados Eye Study Arch Ophthalmol. 1995;113:918–24
    16. Mukamal KJ, Rimm EB. Alcohol’s effects on the risk for coronary heart disease Alcohol Res Health. 2001;25:255–61
    17. Taylor B, Rehm J. Moderate alcohol consumption and diseases of the gastrointestinal system: A review of pathophysiological processes Dig Dis. 2005;23:177–80
    18. Marcus DF, Krupin T, Podos SM, Becker B. The effect of exercise on intraocular pressure. I. Human beings Invest Ophthalmol. 1970;9:749–52
    19. McDaniel DR, Tribbey CL, Tobias GS. Effects of moderate exercise on intraocular pressure Am J Optom Physiol Opt. 1983;60:154–7
      20. Passo MS, Goldberg L, Elliot DL, Van Buskirk EM. Exercise training reduces intraocular pressure among subjects suspected of having glaucoma Arch Ophthalmol. 1991;109:1096–8
      21. Vieira GM, Oliveira HB, de Andrade DT, Bottaro M, Ritch R. Intraocular pressure variation during weight lifting Arch Ophthalmol. 2006;124:1251–4
      22. Kumar DM, Agarwal N. Oxidative stress in glaucoma: A burden of evidence J Glaucoma. 2007;16:334–43
      23. Kang JH, Pasquale LR, Willett W, Rosner B, Egan KM, Faberowski N, et al Antioxidant intake and primary open-angle glaucoma: A prospective study Am J Epidemiol. 2003;158:337–46
      24. Cole GM, Teter B, Grautschy SA. Neuroprotective effects of curcumin Adv Exp Med Biol. 2007;595:197–212
      25. Porcella A, Maxia C, Gessa GL, Pani L. The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein Eur J Neurosci. 2000;12:1123–7
      26. Flach AJ. Delta-9-tetrahydrocannabinol (THC) in the treatment of end-stage open-angle glaucoma Trans Am Ophthalmol Soc. 2002;100:215–22
      27. Green K. Marijuana smoking vs cannabinoids for glaucoma therapy Arch Ophthalmol. 1998;116:1433–7
      28. Chien FY, Wang RF, Mittag TW, Podos SM. Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeys Arch Ophthalmol. 2003;121:87–90
      29. Quaranta L, Bettelli S, Uva MG, Semeraro F, Turano R, Gandolfo E. Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma Ophthalmology. 2003;110:359–62
      30. Grave K, Wienereb R. Medical management of open angle glaucoma 2010 Hague, Netherlands Kurger Publication
      31. Law SK, Li T. Acupuncture for glaucoma Cochrane Database Syst Rev. 2007;4:CD006030

      Publication of the supplement was not supported by any external funding. The Editors, Authors and others involved with the journal did not get any financial or non-financial benefit from any sponsors, unless specified otherwise in the Source of Support at the end of individual articles. I confirm that none of the articles appearing in the Glaucoma Supplement are sponsored articles.

      Source of Support: Nil

      Conflict of Interest: None declared.

      Keywords:

      Alternative and complementary therapy; dietary antioxidants; glaucoma; intraocular pressure; life style

      © 2011 Current Medicine Research and Practice | Published by Wolters Kluwer – Medknow