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Romero, Ivana L1,; Malta, João B N S1,3; Silva, Cely B2; Mimica, Lycia M J2; Soong, Kaz H3; Hida, Richard Y1,4

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Indian Journal of Ophthalmology: Jul–Aug 2010 - Volume 58 - Issue 4 - p 347-348
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Dear Editor,

We appreciate the opinions about our article[1] by Wiwanitkit.[2] The adhesives, mainly ethyl-cyanoacrylate, have been studied by our group in different features.[34] Previously, we mentioned that “high temperatures related to exothermic reaction of ethyl-cyanoacrylate polymerization may possibly induce a temporary bactericidal effect”[3] like Dr Viroj Wiwanitkit cited very well in his letter to the editor. Other studies, however, suggest that the antimicrobial activity could be related to the degradation products.[56] Formaldehyde, one of degradation products of cyanoacrylate, for example, destroys cell membranes by denaturing the membrane proteins.[7] Toxic degradation products of cyanoacrylate may further slow cell growth, damage its physiological needs, and change its cellular membrane structure by inhibiting a specific receptor.[8]


1. Romero IL, Malta JB, Silva CB, Mimica LM, Soong KH, Hida RY. Antibacterial properties of cyanoacrylate tissue adhesive: Does the polymerization reaction play a role? Indian J Ophthalmol. 2009;57:341–4
2. Wiwanitkit V. Cyanoacrylate tissue adhesive Indian J Ophthalmol. 2010;58:347
3. Romero IL, Paiato TP, Silva CB, Nigro JB, Malta S, Jenne Mimica LM, et al Different application volumes of ethyl-cyanoacrylate tissue adhesive can change its antibacterial effects against ocular pathogens in vitro Curr Eye Res. 2008;33:813–8
4. Romero IL, Barreto C, Mimica LMJ, Hida RY. Antimicrobial influence of polymerization process and degradation products of ethyl-cyanoacrylate in vitro for microorganisms related to corneal infection Assoc Res Vis Ophthalmol. 2007;48:4748
5. Refojo MF, Koliopoulos J. Adhesives in ophthalmology Surv Ophthalmol. 1971;15:217–36
6. Trott AT. Cyanoacrylate tissue adhesives.An advance in wound care JAMA. 1997;277:1559–60
7. McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance Clin Microbiol Rev. 1999;12:147–79
8. Reyes GF, Corbett D, Benz FW, Doyle RJ. Acrylonitrile induces autolysis Bacillus subtilis FEMS Microbiol Lett. 2000;182:255–8
© 2010 Indian Journal of Ophthalmology | Published by Wolters Kluwer – Medknow