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Babu, Kalpana; Satish, Vidya; Satish, S1; SubbaKrishna, D K2; Abraham, Mariamma Philips2; Murthy, Krishna R

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Indian Journal of Ophthalmology: Jul–Aug 2010 - Volume 58 - Issue 4 - p 346-347
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Dear Editor,

We wish to thank Chabblani[1] for their interest in this article.[2]

We would like to clarify a few points raised in their letter.

In all patients with a positive quantiferon TB gold test, a detailed systemic evaluation by a chest physician with special interest in tuberculosis followed up with basic laboratory investigations like Mantoux test, ESR, Chest X-ray and liver enzymes were done before labeling them false positives.

It has been mentioned in our article in the 'Materials and methods' that history of prior BCG vaccination could not be obtained in all cases due to inability to recall by the patient or absence of the BCG scar. It is also known that vaccine-induced reactions tend to wane over time and are unlikely to persist over 10 years.[34]

Group C had five out of 21 cases positive for the quantiferon TB gold test. Among the 21 cases in Group C, PPD positivity was seen in two cases. Only one case out of the 21 cases had both PPD and Quanti feron TB gold test positive while 15 of the 21 cases had both tests negative. In Group D, 28 cases out of 39 cases had both tests positive and had intraocular tuberculosis (response to antitubercular therapy). As a result, the specificity and sensitivity remains unchanged.

1. Chhablani J. Comment on: Utility of QuantiFERON Tuberculosis gold test in a south Indian patient population of ocular inflammation Indian J Ophthalmol. 2010;58:346
2. Babu K, Satish V, Satish S, Subbakrishna DK, Abraham MP, Murthy KR. Utility of QuantiFERON TB gold test in a south Indian patient population of ocular inflammation Indian J Ophthalmol. 2009;57:427–30
3. . Centers for Disease Control and Prevention. Screening for tuberculosis and tuberculosis infection in high-risk populations. Recommendations of the Advisory Council for the Elimination of Tuberculosis MMWR Recomm Rep. 1995;44:19–34
4. Bansal R, Gupta A, Gupta V, Dogra MR, Bambery P, Arora SK. Role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis Am J Ophthalmol. 2008;146:772–9
© 2010 Indian Journal of Ophthalmology | Published by Wolters Kluwer – Medknow