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Pseudo-gonio synechia

An artifact on two-mirror gonioscopy

Garudadri, Chandra Sekhar

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Indian Journal of Ophthalmology: Jan–Feb 2010 - Volume 58 - Issue 1 - p 59-60
doi: 10.4103/0301-4738.58473
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Abstract

Gonioscopy is an essential part of the work up for proper diagnosis and classification of glaucoma. The visualization of the angle would vary depending on the optics and the mechanics of lens used. Indentation gonioscopy has been advocated to differentiate between appositional and synechial closure of the angle.[1] Variations in gonioscopic techniques are evident from the published epidemiological studies of glaucoma.[27] As per the World Glaucoma Association's (WGA) consensus statement “The best lens to use remains controversial. Many specialists say that the use of a four-mirror lens is mandatory. Many others disagree. Many closed angles can be “manipulated” open using a Goldmann lens. However, a small proportion of appositionally closed angles cannot. In these cases, the use of a four-mirror lens is mandatory. For this reason, the minimum standard is a four-mirror lens.”[8] In this report we present an additional benefit of indentation gonioscopy.

Case Report

A 45-year-old female patient presented for a routine ophthalmic evaluation. Her visual acuity was 20/20 in each eye without correction, the intraocular pressure was 15 mm Hg in both eyes. The anterior segment examination was unremarkable, with a deep anterior chamber. She underwent gonioscopy as a part of routine complete evaluation. Fig. 1 A, B show the gonioscopic appearance of the angle with what looks like a typical goniosynechia in a wide open angle both with Goldmann (two-mirror) and Sussman (four-mirror) gonioscope. Indentation with the Sussman lens results in the disappearance of the synechia [Fig. 2A] as opposed to the Goldmann lens where in spite of the patient looking towards the mirror, with increased illumination and height of slit beam as well as “manipulation”, the “synechia” persists [Fig. 2B]. This finding we believe is due to a bulge in the periphery of the iris close to the iris insertion, which viewed end-on in gonioscopy looks like a synechia. Indentation flattens the peripheral iris and the bulge making the “synechia” disappear.

Figure 1
Figure 1:
Gonioscopic appearance of the angle showing what looks like a goniosynechia in a wide-open angle a) with Goldmann lens and b) with Sussman lens
Figure 2
Figure 2:
Gonioscopic appearance of the angle shown in Figure 1 on indentaion, showing the a) disappearance of the synechia with Sussman lens and b) persistence of the synechia despite manipulative gonioscopy with Goldmann lens

Discussion

The WGA consensus statement reiterates the difference of opinion among specialists about the ideal gonioscope.[8] The published epidemiological studies on angle closure glaucoma have used varying gonioscopic techniques. There have been two population-based studies in Singapore and Mongolia.[23] In a report looking at the relationship between peripheral anterior synechia (PAS) and angle width the authors found the prevalence of synechiae in wide open angles to vary from 1.88% (Mongolia) to 3.68% (Singapore).[4] In the three epidemiological studies from South India, the prevalence of primary angle closure (PAC) varied from 0.71 to 4.32%.[57] It is possible that the differences in the prevalence of angle closure[57] may in part be due to the differences in methodology of gonioscopy. While manipulative gonioscopy can open the angle in 90-95% of cases, indentation is necessary in the rest.[1] In this case documenting the differentiation of true from pseudo-synechia was possible by indentation gonioscopy with a four-mirror and not by manipulative gonioscopy by a Goldmann gonioscope. We believe that this is an additional advantage of indentation gonioscopy, and indentation gonioscopy is essential to differentiate between pseudo and true goniosynechia.

References

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2. Foster PJ, Baasanhu J, Alsbirk PH, Munkhbayar D, Uranchimeg D, Johnson GJ. Glaucoma in Mongolia - A population-based survey in Hovsgol province, northern Mongolia Arch Ophthalmol. 1996;114:1235–41
3. Foster PJ, Francis TS, Machin OD, Tze-Pin Ng, Joe G, Devereux, et al The Prevalence of Glaucoma in Chinese Residents of Singapore: A Cross-Sectional Population Survey of the Tanjong Pagar District Arch Ophthalmology. 2000;118:1105–11
4. Foster PJ, Aung T, Nolan WP, Machin D, Baasanhu J, Khaw PT, et al Defining “occludable” angles in population surveys: drainage angle width, peripheral anterior synechiae, and glaucomatous optic neuropathy in east Asian people British J Ophthalmology. 2004;88:486–90
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    7. Vijaya L, George R, Arvind H, Baskaran M, Ramesh VS, Raju P, et al Prevalence of primary angle-closure disease in an urban south Indian population and comparison with a rural population. The Chennai Glaucoma Study Ophthalmology. 2008;115:655–60
    8. Foster PJ, He M, Liebmann JF. Epidemiology, classification and mechanism Angle closure and angle closure glaucoma. 2006 The Hague, Netherlands Kugler Publications:15
    Keywords:

    Goldmann gonio lens; indentation gonioscopy; pseudo-synechia; Sussman gonio lens

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