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Clinicopathologic Features and Risk Factors for Recurrence of Mucinous Borderline Ovarian Tumors

A Retrospective Study With Follow-up of More Than 10 Years

Sun, Li, MD*; Li, Ning, MD*; Song, Yan, MD; Wang, Guixiang, MD; Zhao, Zitong, PhD§; Wu, Lingying, MD*

International Journal of Gynecological Cancer: November 2018 - Volume 28 - Issue 9 - p 1643–1649
doi: 10.1097/IGC.0000000000001362
Ovarian Cancer

Objective This study aimed to evaluate the clinicopathologic features of mucinous borderline ovarian tumors (MBOTs), with an emphasis on the risk factors for recurrence.

Methods Data of 76 patients with MBOT diagnosed and treated between 2000 and 2007 at a single institution were analyzed in this retrospective study. The clinicopathologic features of different tumor subgroups were analyzed, including pathology, surgical methodology, recurrence, and overall survival.

Results The median patient age was 40 years (13–85 years). Forty-six patients with gastrointestinal mucinous borderline tumors (intestinal MBOTs) (73.7%) and 20 patients with endocervical MBOT (26.3%) were identified. Forty radical surgeries and 26 conservative surgeries were performed. There were 74.6% patients (50/67) with stage I disease among the 67 patients who received comprehensive surgical staging.

During a median follow-up time of 151 months, 9 recurrences were identified. Median duration from surgery to recurrence was 26.4 months (range, 13–50 months). There was no difference in recurrence rate between intestinal MBOT and endocervical MBOT (14.3% vs 5.0%; P > 0.05). The recurrence rate of stage III tumors was significantly higher than that of stage I (33.3% vs 8%; P < 0.05). The recurrence rate after conservative surgery was higher than that after radical procedures (21.4% vs 6.3%; P < 0.05).

Conclusions The majority of patients with MBOT had a favorable prognosis. Patients with later-stage disease had a higher recurrence rate.

Based on a population-based sample of 2490 ovarian cancer patients, the prognosis is better for MBOTs than typical ovarian tumors; late-stage combined with peritoneal pseudomyxoma is a high-risk factor for the recurrence of MBOT.

Departments of *Gynecological Oncology and

Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing;

Department of Gynecological Oncology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen; and

§State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Address correspondence and reprint requests to Li Sun, MD, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100021. E-mail: sunli@cicams.ac.cn.

The authors declare no conflicts of interest.

Received November 19, 2017

Received in revised form October 9, 2018

Accepted August 20, 2018

© 2018 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.