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Serous Ovarian Cancer Signaling Pathways

Kotsopoulos, Ioannis C. MD*; Papanikolaou, Alexios MD, PhD; Lambropoulos, Alexandros F. PhD; Papazisis, Konstantinos T. MD, PhD; Tsolakidis, Dimitrios MD, PhD; Touplikioti, Panagiota PhD§; Tarlatzis, Basil C. MD, PhD

International Journal of Gynecological Cancer: March 2014 - Volume 24 - Issue 3 - p 410–417
doi: 10.1097/IGC.0000000000000079
Review Articles

Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.

*Obstetrics & Gynecology Department, Medical School, University of Patras, Rion; and †1st Obstetrics & Gynecology Department, Medical School, “Aristotle” University of Thessaloniki; ‡Medical Oncology Department, “Euromedica” General Clinic; and §Cytology Department, “Theagenio” Cancer Hospital, Thessaloniki, Greece.

Address correspondence and reprint requests to Ioannis C. Kotsopoulos, MD, Obstetrics & Gynecology Department, Medical School, University of Patras, Rion, Greece; and Tyrnovou 14, 53100, Florina, Greece. E-mail:

No funding was received for this study.

The authors declare no conflicts of interest.

Received October 2, 2013

Accepted December 1, 2013

© 2014 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.