To Evaluate the Effect of Increasing Maternal Age on Maternal and Neonatal Outcomes in Pregnancies at Advanced Maternal Age : International Journal of Applied and Basic Medical Research

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Original Article

To Evaluate the Effect of Increasing Maternal Age on Maternal and Neonatal Outcomes in Pregnancies at Advanced Maternal Age

Juneja, Sunil Kumar; Tandon, Pooja; Kaur, Gagandeep

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International Journal of Applied and Basic Medical Research 12(4):p 239-242, Oct–Dec 2022. | DOI: 10.4103/ijabmr.ijabmr_193_22
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Every woman has a right to become a mother. Late pregnancies have been a sensitive issue in the society and medical field from many years. Indeed, maternal age has been increasing for several decades with many of these late pregnancies over 40 years of age.[1,2] The reason for this development could be the increasing use of reproductive techniques, the enormous changes in work and society which include higher levels of female employment and educational attainment, and higher number of women working in higher level jobs. The increasing level of education in women who have more responsibilities at work, giving priority to their professional career, delay their childbearing. It has always been a clinical tenet that childbearing in mature age carries elevated maternal and perinatal morbidity and mortality.[3] Many studies have investigated the effect of advanced maternal age on fetal outcome suggesting higher risk of poor neonatal outcome. Recent studies have debated these outcomes.[4] There is a conflicting data supporting motherhood at advanced age in present times. Furthermore there is scarcity of data evaluating the effect of advanced maternal age from Indian population.

Novelty of the study: Advanced maternal age is a significant risk factor for higher maternal and fetal morbidity.


To evaluate the effect of increasing maternal age on maternal and neonatal outcomes in pregnancies at advanced maternal age.

Materials and Methods

The study was conducted on 843 women above the age of 35 years who delivered at Dayanand Medical College and Hospital during 2015–2020. Patients were categorized into two groups: Group A comprised pregnant women aged 35–40 years and Group B included pregnant women aged >40 years. Various other parameters including parity, gestation at delivery, whether the pregnancies were spontaneous or conceived through assisted reproductive techniques (ARTs), and other associated comorbid conditions were noted. The obstetrical, gynecological, medical, surgical, fetal, and neonatal complications were studied in both the groups, and the data were analyzed with release 9.4 (SAS Institute Inc, Cary, NC).

Maternal age was considered as the age at the time of delivery. Gestational age was determined on the basis of either date of last menstrual period or ultrasound examination and in patients with IVF according to date of embryo transfer. Comorbid conditions including cardiac disease (cardiomyopathy, cardiac valvular disease), chronic kidney disease, thyroid disorders, bronchial asthma, chronic liver disease, and autoimmune disease were identified.

The obstetrical, gynecological, medical, and surgical complications observed were gestational hypertension (defined as systolic >140 mmHg and/or diastolic >90 mmHg without proteinuria), preeclampsia (systolic >140 mmHg and/or diastolic >90 mmHg associated with a proteinuria of 24 h >300 mg or severe features), gestational diabetes, abruptio placenta, premature rupture of membranes, postpartum hemorrhage (PPH) (loss of more than 500 cc of blood within 24 h after vaginal delivery or cesarean section), blood transfusion, rupture of ovarian cyst, torsion of ovary or fibroid, red degeneration of fibroid, urinary tract infection (UTI), cholecystitis, appendicitis, and pancreatitis. Admission of women to the intensive care unit during their pregnancies and after delivery was noted.

The fetal and neonatal complications studied were prematurity (birth before 37 weeks), need for neonatal intensive care unit (NICU) care just after the birth, and intrauterine fetal demise.


Categorical variables were reported as number and percentage (percentages were calculated excluding missing data) and were compared by Chi-square test or Fisher’s exact test, as appropriate.

A P < 0.05 was considered significant unless otherwise specified. All statistical analyses were performed with SAS release 9.4 (SAS Institute Inc, Cary, NC) statistical software package.


Out of 843 patients in our study, 81.5% (n = 687) belonged to the age group of 35–40 years. 18.5% (n = 156) belonged to the age group of >40 years.


Out of the 843 patients in our study, 81.5% (n = 687) belonged to the age group of 35–40 years. 18.5% (n = 156) belonged to the age group of >40 years [Table 1]. Patients more than 40 years underwent ART for conception more often (85.3%) as compared to (9.75%) in Group A [Table 2]. Preterm birth was significantly higher in Group B as compared to Group A [Table 3]. Comorbid medical conditions including chronic hypertension, thyroid diseases, autoimmune disorders and obstetric complications such as abortions, oligohydramnios, gestational diabetes mellitus (GDM), placenta previa, and PPH were significantly more common in patients with Group B [Tables 4 and 5]. Cesarean delivery rate was significantly more in Group B as compared to Group A [Table 6]. Neonatal outcome in terms of NICU admissions and preterm birth at <35 weeks gestation was seen more frequently in Group B as compared to Group A [Table 7]. Maternal mortality was higher in Group B than Group A, though the difference was not significant [Table 8].

Table 1:
Distribution of patients with regard to age
Table 2:
Distribution of patients according to the mode of conception
Table 3:
Distribution of patients according to gestation at the time of delivery
Table 4:
Distribution of patients according to comorbid medical condition
Table 5:
Distribution of patients according to the obstetrical, gynecological, and surgical complications
Table 6:
Distribution of patients according to the mode of delivery
Table 7:
Distribution of patients according to the fetal and neonatal outcomes
Table 8:
Distribution of patients according to mortality


Advanced maternal age is an independent risk factor for certain adverse outcomes in pregnancy.[1-3] In our study, out of the 843 patients, 81.5% (n = 687) belonged to the age group of 35–40 years. 18.5% (n = 156) belonged to the age group of >40 years.

The number of patients getting pregnant between the age group of 35 and 40 years is more than patients >40 years of age. In France, the INSEE report shows that the proportion of pregnant women over 35 years rose from 19.3% to 21.3% between 2010 and 2016. This report states that about 5% of women who give birth are 40 years old or older. The age of first pregnancy increased from 29.5 in 2003 to 30.4 in 2016.[5] Decades earlier, a pregnancy was considered “late” if it was obtained after 35 years, today the threshold has shifted to 40 years or even 43 or 45 years according to the scientific literature.[5-7] This is explained by a societal evolution marked by a constantly increasing level of studies by women who have more responsibilities at work and therefore delay their project of childbearing giving their first priority to their professional career.

Demographic trends have seen a significant group of women in their forties seeking reproductive treatments. Although it is well documented that natural fecundity declines with increasing maternal age and the success rates in ART are particularly low for women 40 or older,[8] the cutoff age after which no pregnancies are observed with ART remains elusive and controversial, because there are still acceptable chances for pregnancy in women of this age group. Only recently, the Society for Assisted Reproductive Technology registry has been providing rates of pregnancy and live births for women 43 years of age and older (pregnancy rates of 10.8% and 7.4% for women at ages 43 and 44, with a live birth of 5.1% and 3.0%, respectively) but these data are still limited.

Advances in assisted reproductive technology and increases in the proportion of maternities in older women have both contributed to the steep increase in the incidence of multiple pregnancies since the 1980s. Maternal and perinatal complications are higher in twins than in singleton pregnancies. A significant proportion of perinatal mortality and morbidity among multiple is due to the high incidence of preterm delivery.

Preterm birth is the most important factor determining neonatal morbidity and mortality and has a major impact on it. It has been seen that there is an association between prematurity and advanced maternal age. Lawlor et al., in a population of Danish women, found a U-shaped relationship between maternal age and risk of preterm birth, with the lowest risk age at 24–30 years.[9] Our study corroborates similar findings. A common hypothesis is that the increased risk of preterm birth among aged mothers is largely explained by early labor induction for medical conditions. UTI is associated with preterm labor and occurred more frequently in the women aged >40 years.

GDM was significantly more common in the older age groups as it was associated with decreased insulin sensitivity as with age the pancreatic B cell function and pancreatic sensitivity fall. Women with the predisposition to Type 2 diabetes are therefore more likely to have an inadequate B cell response to stimulation and be more insulin resistant than younger women, which when combined, make gestational diabetes more likely.

Myometrial function deteriorates with age. This mechanism may also be relevant to the increased age-related risk PPH, as uterine atony is the most common cause of PPH. There is also an increased incidence of placenta previa syndrome, retained placenta, and genital lacerations. The incidence of PPH (7.6% in Group B as compared to 1.8% in Group A) and placenta previa (10.8% in Group B as compared to 1.7% in Group A) shows that the incidence of obstetric complications was more in Group B.

We demonstrated a lower prevalence of labor and spontaneous delivery in women of advanced age and a higher rate of cesarean section. A lot of other studies came to similar conclusions citing various comorbidities, previous cesarean section, and fetal macrosomia associated with diabetes mellitus to be the reasons for high rate of operative delivery in older women.[10]

The risk of stillbirth was significantly higher in older women. The risks of aneuploidy and fatal congenital anomalies increase with maternal age and, despite antenatal screening, they are likely to have contributed to the increased rate of stillbirth.


In view of the different maternal profiles, this work attempts to shed more light on the hypotheses surrounding older mothers, postulating higher risks in pregnancy and poorer obstetrical and neonatal outcomes in pregnancies of older mothers. The aim of this study was therefore to evaluate delivery outcomes in a cohort of women at advanced maternal age and to consider the complex impact of medical, surgical, gynecological, and obstetrical factors on delivery outcomes. Our study concludes that the decision to delay childbearing should be discouraged owing to increased maternal and fetal morbidity associated with advanced maternal age, the risks being higher with increasing maternal age.

Ethical statement

The study was approved by the Instituitional Ethics committee, Dayanand Medical College and Hospital, IEC -217.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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Advanced maternal age; comorbidities; preterm birth

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