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Comparison of High Definition with Standard White Light Endoscopy for Detection of Dysplastic Lesions During Surveillance Colonoscopy in Patients with Colonic Inflammatory Bowel Disease

Subramanian, Venkataraman MD, DM, MRCP(UK)*,†; Ramappa, Vidyasagar MD, MRCP(UK); Telakis, Emmanouil MD; Mannath, Jayan MD, MRCP(UK); Jawhari, Aida U. PhD, FRCP; Hawkey, Christopher J. DM, FRCP; Ragunath, Krish MPhil, FRCP

doi: 10.1002/ibd.23002
Original Clinical Articles

Background: Dysplasia in colonic inflammatory bowel disease (IBD) is often multifocal and flat. High-definition (HD) colonoscopy improves adenoma detection rates by improving the ability to detect subtle mucosal changes. The utility of HD colonoscopy in dysplasia detection in patients with IBD has not been reported so far. We aimed to compare the yield of dysplastic lesions detected by standard definition (SD) white light endoscopy with HD endoscopy.

Methods: A retrospective cohort study of patients with long-standing (>7 years) colonic IBD undergoing surveillance colonoscopy at Nottingham University Hospital was studied between September 2008 and February 2010. Details of diagnosis, duration of disease, and outcomes of the colonoscopy were collected from the endoscopy database, electronic patient records, and patient notes.

Results: There were 160 colonoscopies (101 ulcerative colitis [UC] and 59 Crohn's disease [CD]) in the SD group and 209 colonoscopies (147 UC and 62 CD) in the HD group. The groups were well matched for all demographic variables. Thirty-two dysplastic lesions (27 on targeted biopsy) were detected in 24 patients in the HD group and 11 dysplastic lesions (six on targeted biopsy) were detected in eight patients the SD group. The adjusted prevalence ratio of detecting any dysplastic lesion and dysplastic lesion on targeted biopsy was 2.21 (95% confidence interval [CI] 1.09–4.45) and 2.99 (95% CI 1.16–7.79), respectively, for HD colonoscopy.

Conclusions: HD colonoscopy improves targeted detection of dysplastic lesions during surveillance colonoscopy of patients with colonic IBD in routine clinical practice. Randomized controlled studies are required to confirm these findings.

Article first published online 2 May 2012

*Department of Gastroenterology and Leeds Institute of Molecular Medicine, St James University Hospital, Leeds, UK

Nottingham Digestive Diseases Centre, Nottingham University Hospital, UK.

Venkataraman Subramanian was the recipient of an NIHR clinical lecturership from the National Institute of Health Research (UK). Krish Ragunath has received educational/grant support from Olympus (Keymed, UK).

Reprints: Dr. Venkataraman Subramanian, Department of Gastroenterology, St James University Hospital, Leeds LS9 7TF, UK (e-mail:

Received April 08, 2012

Accepted April 09, 2012

© Crohn's & Colitis Foundation of America, Inc.
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