1University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
2Saint Louis University School of Medicine, Saint Louis, Missouri, USA
3Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
4Mayo Clinic, Rochester, Minnesota
5School of Medicine, University of Virginia, Charlottesville, Virginia, USA
6University of Florida College of Medicine, Gainesville, Florida, USA
7National Cancer Institute, Bethesda, Maryland, USA
8University of California, San Diego, San Diego, California, USA
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC, area under the receiver operating characteristic curve; BMI, body mass index; CAP, controlled attenuation parameter; CKD, chronic kidney disease; cT1, corrected T1; CVD, cardiovascular disease; DM, diabetes mellitus; DNL, de novo lipogenesis; DPP-4, dipeptidyl peptidase-4; ELF, Enhanced Liver Fibrosis; FAST, FibroScan-AST; FDA, US Food and Drug Administration; FIB-4, fibrosis-4 index; GH, growth hormone; GLP-1RA, glucagon-like peptide-1 receptor agonist; LDL-C, LDL cholesterol; LSM, liver stiffness measurement; MAST, score derived from MRI-PDFF, MRE, and serum AST; MEFIB, MRE combined with FIB-4; MRE, magnetic resonance elastography; NIT, noninvasive test; OSA, obstructive sleep apnea; PCOS, polycystic ovarian syndrome; PDFF, proton density fat fraction; PIVENS, Pioglitazone versus Vitamin E versus Placebo for the Treatment of Nondiabetic Patients with NASH; RCT, randomized controlled trial; SGLT-2, sodium glucose cotransporter-2; T2DM, type 2 diabetes mellitus; TM6SF2, transmembrane 6 superfamily member 2; UDCA, ursodeoxycholic acid; VCTE, vibration-controlled elastography
Brent A. Neuschwander-Tetri and Rohit Loomba are co-senior authors.
Correspondence Mary E. Rinella, University of Chicago Pritzker School of Medicine Medicine, 5841 S Maryland Avenue, Chicago, IL 60637, USA. Email: [email protected]
