1Department of Pathology, The University of Hong Kong, Hong Kong SAR, China
2Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China
3The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
4Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China
5State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong SAR, China
6Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
7Guangdong‐Hong Kong Joint Laboratory for RNA Medicine, Sun Yat‐Sen University, Guangzhou, China
Abbreviations: CCL2, chemokine (C‐C motif) ligand 2; CD, cluster of differentiation; CDK, cyclin‐dependent kinase; cGAMP, cyclic GMP–AMP; cGAS, cGAMP synthase; ChIP, chromatin immunoprecipitation; CP110, centriolar coiled‐coil protein 110; Ctrl, control; DDX41, DEAD‐box helicase 41; γH2A.X, gamma H2A histone family member X; GI50, 50% growth inhibition; GSEA, gene set enrichment analysis; HDTVi, hydrodynamic tail vein injection; ICI, immune checkpoint inhibitor; IFI16, interferon gamma inducible protein 16; IFN, interferon; IRF, interferon regulatory factor; KD, knockdown; KO, knockout; LOH, loss of heterozygosity; mAb, monoclonal antibody; NK, natural killer; OE, overexpressing; PD‐1, programmed death 1; PD‐L1, programmed death‐ligand 1; PI, propidium iodide; PLK4, polo‐like kinase 4; PTEN, phosphatase and tensin homolog; SA‐β‐Gal, senescence associated β‐galactosidase; SASP, senescence‐associated secretory phenotype; sgRNA, single‐guide RNA; STING, stimulator of interferon genes; TBK1, TANK binding kinase 1; TCGA, The Cancer Genome Atlas; TP53/Trp53, tumor protein P53; WT, wild type.
Funding information Supported by The University of Hong Kong Outstanding Young Researcher Award (to C. C. L. W.) and the Croucher Foundation Croucher Innovation Award (to C. C. L. W.), Health and Medical Research Fund (08192516) (to D. L. and C. C. L. W.)
Correspondence Thomas Chung‐Cheung Yau, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pok Fu Lam, Hong Kong SAR, China. Email: [email protected] Carmen Chak‐Lui Wong, Department of Pathology, The University of Hong Kong, T810 Block T, Queen Mary Hospital, Pok Fu Lam, Hong Kong SAR, China. Email: [email protected]
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