Publication Only: Acute lymphoblastic leukemia - Clinical
Hematologic malignancies are a great public health problem in the World. These cancers of hematopoietic system are responsible for many deaths every year. But it exists some disparities in geographic repartition and in the lethality associated factors.
The aim of this study was to describe a profil of major causes of deaths by hematologic malignancies in a West Africa' country in order to establish the state of art and create a north south cooperation.
We conducted a retrospective study from medical files of patients who was hospitalised or followed in external consultations in the department of Internal Medicine at University Hospital Yalgado Ouedraogo in Ouagadougou (Burkina Faso). The study period go from 1st January to 31th December 2016. Only patients over than 15 years old have been inclued.
The study population collected was 122 patients. Hematologic malignancies represented 80,33% (98/122) of patients. The annual incidence of hematologic malignancies was 8,16 cases.
The mean age was 53,51 years [15 - 84]. The sex-ratio (M/W) was de 1,51. The repartition of frequences was: Acute Myeloid Leukemia (AML)= 2,04%, Acute Lymphoblastic Leukemia (ALL)= 6,12%, Myeloproliferative Syndroms (MS)= 10,20%, Lymphoproliferative Syndroms (LS)= 76,53%, Myelodysplasic Syndroms (MDS)= 5,11%.
Infections was the most frequent etiology of death with 52,95% and the most lethal was pulmonary infection (29,42%). The range age [15-30 years[had the highest rate of lethaly (83,33%). The most lethal disease was ALL with 66,67%. The chemotherapy with poor survival was Bleomycin-CHOP with a lethality of 33,33%.
The main associated factor to their lethality was infection and the worst prognosis's cancer was acute lymphoblastic leukemia. We hope that with a better partnership with developped countries and the sharing of experience we will improve our overall survival and the global prognosis of these diseases.