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THE EFFECTS OF CURCUMIN ADDITION ON REMISSION STATUS OF MULTIPLE MYELOMA PATIENTS

PB2172

Santosa, D.1; Suharti, C.2; Riwanto, I.3; Dharmana, E.4; Adi Pangarsa, E.2; Setiawan, B.2; Suyono, S.2; Tobing, Lumban M.2

doi: 10.1097/01.HS9.0000567168.14031.ac
Publication Only: Myeloma and other monoclonal gammopathies - Clinical
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1Division of Hematology-Medical Oncology, Department of Internal Medicine

2Division of Hematology-Medical Oncology, Departement of Internal Medicine, School of Medicine, Diponegoro University/Dr. Kariadi Hospital

3Department of Surgery, School of Medicine, University/Dr. Kariadi Hospital

4Department of Parasitology, School of Medicine, Diponegoro University, Semarang, Indonesia

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Background:

The standard treatment for multiple myeloma (MM) which ineligible transplant is melphalan prednisone (MP). Curcumin has anti-inflamatory, anti angiogenesis, decrease proliferation and delay progression of monoclonal gammopathy undetermined significant or smoldering myeloma. There is no study of curcumin in MM patients

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Aims:

To evaluate the effect of curcumin addition to remission status at MM patient with regiment MP

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Methods

This experimental study was involved 35 patients which randomly into treatment (n = 17) and control (n = 16). The treatment group was given melphalan 4 mg/m2, prednisone 40 mg/m2 (MP) for 7 days and curcumin 8 gram daily for 28 days. The control group was given MP and placebo. Remision status was evaluated after 4 cycles treatment. The difference between two groups was analysed by Mann-Whitney U-Test. Trend analysis was evealuated by Friedman. Remission status was evaluated by Chi-square. Multivariate analysis was evaluated by multiple logistic regression.

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Results:

There was a significant decrease of NF-KB, VEGF, TNF-α, LDH levels in the treatment group compared with control. There was a decreasing trend of IL-6 levels in the treatment group significantly. There was significant difference of remission status beetween the treatment and control group [(75 vs 33.3), X2 = 6.89,df = 1, p = 0.009]. There was significant correlation between TNF-α levles and remission status [OR = 1.35; (95% CI = 1.03-1.7.6), p = 0.03].

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Summary/Conclusion:

The curcumin addition on MM patient with MP regiment improved the remision status through decreased of TNF-α levels.

Copyright © 2019 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the European Hematology Association.