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CHARACTERISTICS OF ERYTHROLEUKEMIA ABOUT 10 CASES WITH REVIEW OF THE LITERATURE

PB1765

Talbi, T. F.1; abbadi, M. R.1; ghassoul, Y.1; djilali, M.1; belateche, K.1; bouteldja, L.1; menouer, S.1; ardjoun, F. Z.1; belakhel, S.1; djouadi, K.1

doi: 10.1097/01.HS9.0000565568.81500.a2
Publication Only: Acute myeloid leukemia - Clinical
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1hematology, military hospital, algiers, Algeria

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Background:

Acute erythroblastic leukemia (AML-M6) is a rare entity, accounting for 3-4% of all LAs. There are two types: erythroleukemia and pure erythroid leukemia. It is most often manifested by signs of cytopenia and infiltration of extrahematopoietic tissues, and is more common in adults than in children with a poor prognosis.

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Aims:

The objective of this study is to describe the clinical, biological and evolutionary aspects of erytholeukemia in a monocentric retrospective study.

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Methods:

the diagnosis is based on a cytological examination of the blood smear (FS) and medullary (PMO) as well as the immunophenotypic examination. We calculated overall survival by Kaplan Meier method

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Results:

n = 181 (evaluable), n = 10 patients with AML6 according to the FAB classification (5%). • The cytological study of FS and PMO + CMF results led to the diagnosis of erythroleukemia in 08 of our patients and pure erythroid leukemia in 2 patients. Mean age = 47 ± 21.77 years [0-64]. Sex ratio = 1.5 (6H / 4F) .Duration: 40 ± 35 days [01-90] .Symptoms of bone marrow failure: PCM (100%), hemorrhagic syndrome: 3 cases (30%), infection: 04 cases (40%), splenomegaly: 04 cases (30%), mean WB = 84,300 ± 11.260 giga / l [125.000-83.400], peripheral blast level (avg = 26 ± 23% [1-65]), medullary blasts = average 49.5 ± 19% (08-93) • mean hemoglobin level = 8.06 ± 1.09 g / dl [5-10], platelets: 21-151giga / l (avg: 65,900 ± 47,450 / mm3) n = 03 patients had severe thrombocytopenia at 13-21-39 giga / respectively (30%), pancytopenia found in n = 05 cases (50%), LDH level (mean) = 905 ± 896 IU / L [12-2,900], n = 02 patients had 1 metabolic complication at diagnosis (hyperkalemia, hyponatremia) .n = 8 patients received induction CT (3 + 7), n = 01 patient received only 2 aracytin-associated antracycline injections. Newborn LAM, the newborn clinically presents: cutaneous and mucosal paleness and hepatosplenomegaly, on the biological plane: GB: 125giga / l, (EB = 64%, blast = 3%), HB = 10 g / dl, PLQ = 13gigal / l, PMO: infiltration by 68% of dystrophic EB, 08% of MB, the newborn t under aseptic vacuum The specific treatment has not yet been started. The complete remission is obtained (n = 04 cases (40%)) and n = 03 failures (30%), n = 01patient came out against medical advice; one induction death is listed (acute cardiac toxicity) • Overall survival = 27% (fig1)

Figure

Figure

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Summary/Conclusion:

our data are similar to those of the literature: rare pathologic LAM6 (3-5 / series, 05% in ours), exceptional in children. The signs of bone marrow failure are almost constant, 1 pancytopenia in 50%. Splenomegaly is found in 1/3 of the cases. The prognosis is reserved (overall survival = 25% at 05 years) from wherethe value of rapid diagnosis and adequate management

Copyright © 2019 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the European Hematology Association.