1Institute of Molecular Medicine and Cell Research (IMMZ), University of Freiburg, Freiburg, Germany
2Faculty of Medicine, University of Freiburg, Freiburg, Germany
3Faculty of Biology, University of Freiburg, Freiburg, Germany
4Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany
5Department of Hematology and Oncology, Medical Center, University of Freiburg, Freiburg, Germany
6Department of Pathology, Institute for Surgical Pathology, Medical Center, University of Freiburg, Freiburg, Germany
7Comprehensive Cancer Center Freiburg, Medical Center, University of Freiburg, Freiburg, Germany
8BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany
9German Cancer Consortium (DKTK, Freiburg) and German Cancer Research Center (DKFZ), Heidelberg, Germany
Correspondence: Sebastian Halbach and Tilman Brummer (e-mail: Sebastian.Halbach@mol-med.uni-freiburg.de [SH], Tilman.Brummer@mol-med.uni-freiburg.de [TB]).
Citation: Sies K, Spohr C, Gründer A, Todorova R, Uhl FM, Huber J, Zeiser R, Pahl HL, Becker H, Aumann K, Brummer T, Halbach S. Gab2 Is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia. HemaSphere, 2019;00:00. http://dx.doi.org/10.1097/HS9.0000000000000184
Funding/support: This study was supported in part by the Excellence Initiative of the German Research Foundation (GSC-4, Spemann Graduate School, BIOSS EXC 294), the Heisenberg program (TB), the José Carreras Leukämie-Stiftung e.V. and the Deutsche Krebshilfe (Mildred-Scheel-Doktoranden-Program, 111815 to K.S.).
Disclosure: The authors have indicated they have no potential conflicts of interest to disclose.
KS and CS have contributed equally to this study.
TB and SH are co-senior authors.
All authors designed, analyzed, and discussed experiments. KS, CS, AG, FMU, and SH performed all cellular and biochemical experiments. KA, RT, and JH conducted the histological analysis. HB, HLP, and RZ provided clinical samples and/or expertise. SH wrote the manuscript together with KS, CS, HB, KA, and TB. All authors reviewed and commented on the manuscript and accepted its final version.
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Received January 22, 2019
Accepted January 25, 2019