N. V. Ilyin, J. N. Vinogradova, E. I. Ivanova
FSBI “Russian Research Center for Radiology and Surgical Technologies name by acad. Granov” of the Ministry of Health Care, St. Petersburg, Russian Federation
Purpose: We evaluated the results and early complications at 2D-radiotherapy (RT) for above diaphragm stage II Hodgkin Lymphoma (HL) with conventional (CF) and multifractionation (MF) dose.
Patients and methods: From 1986 to 2013 ys 237 patients (pts) with above diaphragm stage II HL had chemotherapy 3–4 cycles ABVD than there was 2D-RT: mantle – 117 pts before 2002y or IFRT – 120 pts after 2002 y; with CF (89 pts) or MF (148 pts); 1,35 Gy twice a day in 4 hours 30–36 Gy.
Results: 235 pts (99,2%) entered the state of remission; 2 pts had progressive disease. Recurrences induced in 19 (8,1%) pts: 7,5% MF-RT and 9,0% - CF-RT (p > 0,1). Overall and recurrence-free 10-year survival were 98% (CF-RT) and 85% (CF-RT); 99% and 86% (MF-RT) respectively (p > 0,1). Early complications (pulmonitis, pericarditis, esophagitis) at pts with involved mediastinum (123 pts) were more after at mantle, then IFRT; similar at CF and MF-pts (pericarditis, esophagitis), but pulmonitis were less often at pts with MF-RT (8% vs 20%), p < 0,05.
Conclusion: CF- and MF-RT had similar antitumour results (relapses; survival), but early pulmonitis were less often at MF-RT pts.