P023 (0003) CONVENTIONAL VS MULTIFRACTIONATION AT RADIOTHERAPY FOR ABOVE DIAPHRAGM STAGE II HODGKIN LYMPHOMA

30-YEAR EXPERIENCE OF SINGLE CENTER

doi: 10.1097/01.HS9.0000547873.72351.2c
Early Stages
Free

N. V. Ilyin, J. N. Vinogradova, E. I. Ivanova

FSBI “Russian Research Center for Radiology and Surgical Technologies name by acad. Granov” of the Ministry of Health Care, St. Petersburg, Russian Federation

Purpose: We evaluated the results and early complications at 2D-radiotherapy (RT) for above diaphragm stage II Hodgkin Lymphoma (HL) with conventional (CF) and multifractionation (MF) dose.

Patients and methods: From 1986 to 2013 ys 237 patients (pts) with above diaphragm stage II HL had chemotherapy 3–4 cycles ABVD than there was 2D-RT: mantle – 117 pts before 2002y or IFRT – 120 pts after 2002 y; with CF (89 pts) or MF (148 pts); 1,35 Gy twice a day in 4 hours 30–36 Gy.

Results: 235 pts (99,2%) entered the state of remission; 2 pts had progressive disease. Recurrences induced in 19 (8,1%) pts: 7,5% MF-RT and 9,0% - CF-RT (p > 0,1). Overall and recurrence-free 10-year survival were 98% (CF-RT) and 85% (CF-RT); 99% and 86% (MF-RT) respectively (p > 0,1). Early complications (pulmonitis, pericarditis, esophagitis) at pts with involved mediastinum (123 pts) were more after at mantle, then IFRT; similar at CF and MF-pts (pericarditis, esophagitis), but pulmonitis were less often at pts with MF-RT (8% vs 20%), p < 0,05.

Conclusion: CF- and MF-RT had similar antitumour results (relapses; survival), but early pulmonitis were less often at MF-RT pts.

Copyright © 2018 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the European Hematology Association.