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Development of the Plutonium-DTPA Biokinetic Model

Konzen, Kevin*; Brey, Richard

doi: 10.1097/HP.0000000000000283

Estimating radionuclide intakes from bioassays following chelation treatment presents a challenge to the dosimetrist due to the observed excretion enhancement of the particular radionuclide of concern where no standard biokinetic model exists. This document provides a Pu-DTPA biokinetic model that may be used for making such determination for plutonium intakes. The Pu-DTPA biokinetic model is intended to supplement the standard recommended biokinetic models. The model was used to evaluate several chelation strategies that resulted in providing recommendations for effective treatment. These recommendations supported early treatment for soluble particle inhalations and an initial 3‐day series of DTPA treatments for wounds. Several late chelation strategies were also compared where reduced treatment frequencies proved to be as effective as multiple treatments. The Pu-DTPA biokinetic model can be used to assist in estimating initial intakes of transuranic radionuclides and for studying the effects of different treatment strategies.

*CH2M-WG Idaho, LLC, Radiological Control, 1580 Sawtelle Street, Idaho Falls, ID 83402; †Department of Nuclear Engineering and Health Physics, Idaho State University, 921 South 8th Avenue, Stop 8060, Pocatello, ID 83209‐8060.

The authors declare no conflicts of interest.

For correspondence contact: Kevin Konzen, CH2M-WG Idaho, LLC., 1580 Sawtelle Street, Idaho Falls, ID 83402, or email at

(Manuscript accepted 15 April 2014)

© 2015 by the Health Physics Society