Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Estimating Risk of Hematopoietic Acute Radiation Syndrome in Children

Adams, Tim G.; Sumner, Louise E.; Casagrande, Rocco*

doi: 10.1097/HP.0000000000000720
Papers
Buy

Following a radiological terrorist attack or radiation accident, the general public may be exposed to radiation. Historically, modeling efforts have focused on radiation effects on a “reference man”—a 70‐kg, 180‐cm-tall, 20‐ to 30‐y-old male—which does not adequately reflect radiation hazard to special populations, particularly children. This work examines the radiosensitivity of children with respect to reference man to develop a set of parameters for modeling hematopoetic acute radiation syndrome in children. This analysis was performed using animal studies and the results verified using data from medical studies. Overall, the hematopoietic system in children is much more radiosensitive than that in adults, with the LD50 for children being 56% to 91% of the LD50 of adults, depending on age.

*Gryphon Scientific LLC., Takoma Park, MD 20912.

The authors declare no conflicts of interest.

For correspondence contact: Tim G. Adams, 6930 Carroll Ave, Suite #810, Takoma Park, MD, 20912, or email at tadams@gryphonscientific.com.

(Manuscript accepted 12 July 2017)

© 2017 by the Health Physics Society