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Considerations for Bioassay Monitoring of Mixtures of Radionuclides

Klumpp, John*; Waters, Tom*; Bertelli, Luiz*

doi: 10.1097/HP.0000000000000707
Operational Topics

Complying with regulations for bioassay monitoring of radionuclide intakes is significantly more complex for mixtures than it is for pure radionuclides. Different constituents will naturally have different dose coefficients, be detectable at significantly different levels, and may require very different amounts of effort to bioassay. The ability to use certain constituents as surrogates for others will depend on how well characterized the mixture is, as well as whether the employee is also working with other radionuclides. This is further compounded by the fact that the composition of a mixture (or even of a pure radionuclide) is likely to change over time. Internal dosimetrists must decide how best to monitor employees who work with radionuclide mixtures. In particular, they must decide which constituents should be monitored routinely, which constituents only need to be monitored in the case of an intake, and how to estimate doses based on intakes of monitored and unmonitored constituents.

*Los Alamos National Laboratory, PO Box 1663, Mail Stop G761, Los Alamos, NM 87545.

The authors declare no conflicts of interest.

John Klumpp is an Internal Dosimetrist at Los Alamos National Laboratory. He obtained his M.S. in medical physics and his Ph.D. in radiological health sciences. His research focuses on interpretation of counting measurements, lung deposition of radioactive aerosols, and development of new biokinetic models. His email is

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