Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development

Carter, Claire L.*; Jones, Jace W.*; Barrow, Kory; Kieta, Kaitlyn; Taylor-Howell, Cheryl; Kearney, Sean; Smith, Cassandra P.; Gibbs, Allison; Farese, Ann M.; MacVittie, Thomas J.; Kane, Maureen A.*

doi: 10.1097/HP.0000000000000353
Papers
Buy
SDC

Radiation-induced lung injury is highly complex and characterized by multiple pathologies, which occur over time and sporadically throughout the lung. This complexity makes biomarker investigations and medical countermeasure screenings challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has the ability to resolve differences spatially in molecular profiles within the lung following radiation exposure and can aid in biomarker identification and pharmaceutical efficacy investigations. MALDI-MSI was applied to the investigation of a whole-thorax lung irradiation model in non-human primates (NHP) for lipidomic analysis and medical countermeasure distribution.

Supplemental digital content is available in the text.

*University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD 21201; †University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD 21201.

The authors declare no conflicts of interest.

For correspondence contact: Maureen A. Kane, Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine Street, Room N706, Baltimore, MD 21201, or email at mkane@rx.umaryland.edu.

Supplemental Digital Content is available in the HTML and PDF versions of this article on the journal's Web site (www.health-physics.com).

(Manuscript accepted 9 September 2015)

© 2015 by the Health Physics Society