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Software for Empirical Building of Biokinetic Models for Normal and Decorporation-affected Data

Miller, Guthrie; Bertelli, Luiz*; Klare, Kenneth; Weber, Waylon; Doyle-Eisele, Melanie; Guilmette, Raymond

doi: 10.1097/HP.0b013e318265e0c3
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This paper describes software (“RATDOSE”) developed to analyze data from animal experiments investigating the efficacy of chelating agents. An empirical model building approach is used where, starting from the simplest model structures, one minimizes χ2 by varying transfer rates in the model. Model complexity is increased as needed until the minimum attained value of χ2 per data point decreases to about 1. This approach requires careful treatment of data uncertainties and independent checks of data self-consistency. The biokinetic models can include second-order kinetics to describe the chelation chemical reaction. The radiation dose to the animal is also calculated using S quantities specific for the animal, although the tissue weighting factors used to calculate the effective dose are those for the human.

*Los Alamos National Laboratory; †Lovelace Respiratory Research Institute.

The authors declare no conflicts of interest.

For correspondence contact: Raymond A. Guilmette, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, or email at rguilmette@lrri.org.

(Manuscript accepted 21 June 2012)

© 2012 by the Health Physics Society