NEW EMERGING CONCEPTS IN THE MEDICAL MANAGEMENT OF LOCAL RADIATION INJURY : Health Physics

Secondary Logo

Journal Logo

Session 5. Towards Global Consensus on Medical Management of Radiation Injuries: 5-B. Local Radiation Injuries and Combined Injuries Management: Note

NEW EMERGING CONCEPTS IN THE MEDICAL MANAGEMENT OF LOCAL RADIATION INJURY

Benderitter, Marc*; Gourmelon, Patrick*; Bey, Eric; Chapel, Alain*; Clairand, Isabelle*; Prat, Marie; Lataillade, Jean Jacques

Author Information
Health Physics 98(6):p 851-857, June 2010. | DOI: 10.1097/HP.0b013e3181c9f79a

Abstract

Treatment of severe radiation burns remains a difficult medical challenge. The response of the skin to ionizing radiation results in a range of clinical manifestations. The most severe manifestations are highly invalidating. Although several therapeutic strategies (excision, skin grafting, skin or muscle flaps) have been used with some success, none have proven entirely satisfying. The concept that stem cell injections could be used for reducing normal tissue injury has been discussed for a number of years. Mesenchymal stem cells therapy may be a promising therapeutic approach for improving radiation-induced skin and muscle damages. Pre-clinical and clinical benefit of mesenchymal stem cell injection for ulcerated skin and muscle restoration after high dose radiation exposure has been successfully demonstrated. Three first patients suffering from severe radiological syndrome were successfully treated in France based on autologous human grade mesenchymal stem cell injection combined to plastic surgery or skin graft. Stem cell therapy has to be improved to the point that hospitals can put safe, efficient, and reliable clinical protocols into practice.

©2010Health Physics Society

Full Text Access for Subscribers:

You can read the full text of this article if you:

Access through Ovid