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DIFFICULTY IN DISLODGING IN VIVO FIXED RADIOSTRONTIUM

Sonawane, V. R.; Jagtap, V. S.; Pahuja, D. N.; Rajan, M. G. R.; Samuel, A. M.

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Many trials based on the basic phenomena of isotopic dilution, adsorption, ion exchange, chelation, etc., have been attempted for the decorporation of radiostrontium, particularly 90Sr, after its entry in the in vivo system. We have recently demonstrated a non-isotopic carrier effect of some common calcium salts (calcium = 9 mg mL−1) to reduce the whole body retention of radiostrontium, if administered within 2 h after radiostrontium exposure and furthermore once daily, in rats, supplemented with calcium fortified diet. However, 25–30% of radiostrontium (compared to 50–60% in untreated animals) was still found to be retained in the animal even after 2 wk of treatment. Trial of some simple interventional measures, which would not adversely affect the animal metabolism, like pyrophosphate and magnesium sulfate, sodium citrate, chitin (a bio-absorbent), crown ether (a metal-chelator), and ammonium chloride, was therefore attempted to dislodge this remaining radiostrontium by switching over these animals to normal diet and subjecting them to different lines of treatment with these simple interventions through diet and drinking water separately for a further 4 wk. However, this remaining portion of radiostrontium is fixed in the bone and is difficult to dislodge.

* Laboratory Nuclear Medicine Section (Isotope Group), c/o Tata Memorial Hospital Annexe, Parel. Mumbai, 400 012, India; Former Director, Bio-Sciences & Medical Group, B.A.R.C.

For correspondence or reprints contact: D. N. Pahuja, Laboratory Nuclear Medicine Section (Isotope Group), c/o Tata Memorial Hospital Annexe, Parel. Mumbai, 400 012, India, or email at palpahuja@yahoo.co.in or pahujarmc@hotmail.com.

(Manuscript received 4 September 2003; revised manuscript received 12 January 2004, accepted 31 March 2004)

© 2004 by the Health Physics Society