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Crawley F. E. H.; Goddard, Elizabeth A.
Health Physics: March 1977
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The metabolism of carbon-14 labelled potassium cyanide in the rat after intravenous injection, pulmonary and gastric intubation and skin absorption has been studied. The pattern of excretion and tissue levels of the carbon-14 activity was similar for the intravenous and pulmonary routes but some differences in tissue distribution were apparent after skin absorption. After intravenous injection 45% of the administered activity was excreted in the urine within 24 hr and 74% by 60 days after administration. The corresponding values after 60 days were 8% for breath and 15% for faeces. The time integrals of concentration of the activity in the body have been determined from the cumulative excretion data and the internal dose from carbon-14 labelled potassium cyanide calculated. The committed human dose equivalent to whole body from an intake of 1 μCi was calculated to be 1.6 × 10−4 rems.

©1977Health Physics Society