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Harley Naomi H.; Pasternack, Bernard S.
Health Physics: January 1976
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The alpha dose to cell nuclei on human trabecular bone surfaces critical to osteosarcoma production has been computed. The dose calculations are performed for 226Ra and its daughters, and for 239Pu incorporated into bone. The dose rates are computed utilizing measured values of the alpha energy loss (stopping power) in polycarbonate which has an ionization potential similar to tissue. Recent data such as the ICRP Task Group radium retention (ICRP, 1973) for trabecular bone have been incorporated into the model. Trabecular bone cell dose rates are also calculated for the mouse and beagle dog and the results agree with observed individual toxicities and relative Pu/Ra toxicities. Results for human bone indicate that the accumulated dose to cells on trabecular bone surfaces is highly dependent upon the burial of plutonium due to bone growth. A sustained ICRP maximum permissible body burden of 0.1 μCi of 226Ra will give 8 cads to these cells in 10 yr whereas a maximum permissible body burden of 0.04 μCi of 239Pu yields 18 rads. The 30-yr values for these sustained skeletal burdens are 25 and 30 rads respectively.

©1976Health Physics Society