Data are given from investigations into the production of radioactive test aerosols and studies of lung clearance in the rabbit. Lung clearance was measured using a specially developed profile scanning technique. This technique made it possible to follow the clearance rate from repeated measurements of the lung activity in a single animal. Furthermore, the animal could be re-exposed. Heterodisperse radioactive aerosols were used initially; more recently, monodisperse aerosols have been used. Monodisperse radioactive aerosols in the particle range 1–10 micro have hitherto been produced mainly by a modified LaMer method for lung clearance studies. Monodisperse radioactively tagged plastic aerosols have also been produced by the spinning disk technique, and methods for iodinating (with 131I) latex particles are in progress.
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