Total-body irradiation techniques using massive doses of chelated Y90 administered intravenously in dogs; monkeys and man for the selective destruction of lymphatic tissue have been developed by biomedical research personnel at Lawrence Radiation Laboratory, Berkeley. Purchase cost and assurance of purity necessitate Y90 production at the site from a multicurie Sr90 source. Health physics problems included design and construction of shielded and remotely operated Y90 extraction equipment, equipment for preliminary animal experimentation, multipurpose containers for efficient and safe utilization of curie quantities of beta emitters, enclosures for dogs and monkeys during isotope infusion in the hundreds of mc range, and enclosures for long-term maintenance of these animals. Provision was made for simple decontamination and waste processing. An enclosure was designed to comfortably house a human patient and the medical equipment for his treatment. This enclosure provides adequate shielding for the attending medical team, yet permits rapid access in case of a medical emergency. Methods were also developed to prevent spread of radioactive contamination following transfer of the patient to a pressurized reverse isolation hospital room.
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