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Family History of Migraine Associated With Posttraumatic Migraine Symptoms Following Sport-Related Concussion

Sufrinko, Alicia PhD; McAllister-Deitrick, Jamie PhD; Elbin, RJ PhD; Collins, Michael W. PhD; Kontos, Anthony P. PhD

Section Editor(s): Caplan, Bruce PhD, ABPP; Bogner, Jennifer PhD, ABPP; Brenner, Lisa PhD, ABPP; Malec, James PhD, ABPP

The Journal of Head Trauma Rehabilitation: January/February 2018 - Volume 33 - Issue 1 - p 7–14
doi: 10.1097/HTR.0000000000000315
Original Articles
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Objective: To determine whether family history of migraine increased the likelihood of posttraumatic migraine (PTM) symptom presentation in adolescents following concussion, and examine the influence of family history of migraine and PTM on postinjury outcomes.

Setting: Outpatient concussion clinic.

Participants: A total of 153 patients with concussion (103 males and 50 females) aged 15.72 ± 1.48 years (range 12–18 years).

Design: Cross-sectional, observational study of patients presenting for initial evaluation 4.72 ± 3.05 days (range 1–14) postinjury.

Main Measures: Computerized neurocognitive testing, symptom report, and vestibular/oculomotor screening.

Results: Patients with a family history of migraine were 2.6 times (odds ratio = 2.60, confidence interval = 1.35–5.02, P = .003) more likely to present with PTM compared with patients without a family history. Results of multivariate analyses of covariance, controlling for concussion history, revealed significant main effects for PTM on (1) Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT)/Post-Concussion Symptom Scale (PCSS) (F = 15.43, P <.001) and (2) Vestibular/Ocular Motor Screening (VOMS) (F = 8.52, P < .001). There was no main effect for family history of migraine on ImPACT/PCSS (P = .22) and VOMS (P = .83) or interaction between family history of migraine and PTM on ImPACT/PCSS (P = .84) and VOMS (P = .52).

Conclusion: Family history of migraine is associated with PTM symptoms following sport-related concussion, suggesting a genetic predisposition for migraine may serve as a catalyst or trigger for onset of PTM. However, only presence of PTM, rather than family history of migraine, was related to worse neurocognitive and vestibular/oculomotor outcomes.

UPMC Sports Medicine Concussion Program, Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania (Drs Sufrinko, McAllister-Deitrick, Collins, and Kontos); and Department of Health, Human Performance and Recreation/Office for Sport Concussion Research, University of Arkansas, Fayetteville (Dr Elbin).

Corresponding Author: Alicia Sufrinko, PhD, Department of Orthopaedic Surgery, University of Pittsburgh, 3200 S. Water St, Pittsburgh, PA 15221 (sufrinkoam@upmc.edu).

Michael W. Collins is a cofounder and 10% shareholder of ImPACT Applications, Inc.

This research was supported in part by a grant to the University of Pittsburgh from the National Institute on Deafness and Other Communication Disorders (1K01DC012332-01A1) to Dr Kontos.

The authors declare no conflicts of interest.

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.