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Efficacy of Amantadine Treatment on Symptoms and Neurocognitive Performance Among Adolescents Following Sports-Related Concussion

Reddy, Cara Camiolo MD; Collins, Michael PhD; Lovell, Mark PhD; Kontos, Anthony P. PhD

Section Editor(s): Caplan, Bruce PhD, ABPP; Bogner, Jennifer PhD, ABPP

The Journal of Head Trauma Rehabilitation: July/August 2013 - Volume 28 - Issue 4 - p 260–265
doi: 10.1097/HTR.0b013e318257fbc6
Concussion in Sports: 2013

Objective: To evaluate the efficacy of amantadine in the treatment of symptoms and neurocognitive performance in adolescents following sports-related concussion.

Participants: A clinical sample of 25 male (n = 11) and female (n = 14) adolescent subjects with an age-, sex-, and concussion history–matched group of 25 male (n = 11) and female (n = 14) control subjects.

Setting: Outpatient concussion clinic.

Intervention: Retrospective, case-control design. Treatment group consisted of patients treated with 100 mg of amantadine twice daily (200 mg total per day) following a period of rest. Matched controls were evaluated and treated conservatively without medication at the same concussion program prior to the start of the current amantadine protocol.

Main Outcome Measures: Immediate Postconcussion Assessment and Cognitive Test computerized neurocognitive test battery and symptom report.

Results: Results support significantly greater improvements from pre- to posttest in reported symptoms, verbal memory, and reaction time performance for the amantadine group than the matched controls. There were no significant differences for visual memory or visual motor processing speed.

Conclusion: This study provides empirical support for amantadine as an effective pharmacologic treatment of certain concussion-related cognitive deficits and symptoms in athletes with protracted recovery of more than 3 weeks.

Departments of Physical Medicine and Rehabilitation (Dr Camiolo Reddy) and Orthopedic Surgery (Drs Camiolo Reddy, Collins, Lovell, and Kontos), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Corresponding Author: Cara Camiolo Reddy, MD, Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, 1400 Locust St D-G103, Pittsburgh, PA 15219 (

The authors thank Rosanna Sabini, DO, and Maria Twichell, MD, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, for assistance in manuscript writing.

Drs Camiolo Reddy and Kontos had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Michael W. Collins, PhD and Mark R. Lovell, PhD, are stockholders in ImPACT Applications, Inc, the company that develops and sells ImPACT software. None of the other authors have any financial or other conflicts of interests to disclose.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins