Original ArticlesThe Vegetative and Minimally Conscious States Current Knowledge and Remaining QuestionsGiacino, Joseph PhD; Whyte, John MD, PhD Author Information JFK Johnson Rehabilitation Institute, Edison, NJ (Dr Giacino); and the Moss Rehabilitation Research Institute, Philadelphia, Pa (Dr Whyte). Corresponding author: Joseph Giacino, PhD, JFK Johnson Rehabilitation Institute, 65 James St, Edison, NJ (e-mail: [email protected]). This work was supported in part by grant H133A031713 from the National Institute on Disability and Rehabilitation Research. The authors thank Mary Czerniak for assistance in preparation of the manuscript. Journal of Head Trauma Rehabilitation: January 2005 - Volume 20 - Issue 1 - p 30-50 Buy Abstract In the last 2 decades, the minimally conscious state has been distinguished conceptually from the vegetative state and operational criteria for these diagnoses have been published. Standardized and individualized assessment tools have been developed to assist with the diagnosis of severe disorders of consciousness and the measurement of clinical improvement. The natural course of recovery and the importance of key prognostic predictors have been elucidated. Important advances have also been made in defining the similarities and differences in the pathophysiology of these two states, and functional imaging modalities have begun to explicate the neural substrate underlying the behavioral features of these disorders. Research on the efficacy of treatments for severe disorders of consciousness lags behind, due to the practical and ethical difficulties in executing large rigorously controlled clinical trials. The past and future scientific developments in this area provide an important background for continuing discussions of the ethical controversies surrounding end-of-life decision making and resource allocation. © 2005 Lippincott Williams & Wilkins, Inc.