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Serotonin Agents in the Treatment of Acquired Brain Injury

Zafonte, Ross D. DO; Cullen, Nora MD, MS; Lexell, Jan MD, PhD

The Journal of Head Trauma Rehabilitation: August 2002 - Volume 17 - Issue 4 - p 322–334
Selected Reviews in Psychopharmacology

Background: The development of novel serotonin agents has led to an increased use of these medications throughout medical practice. An understanding of the basic pharmacological function of these agents is key to understanding their usefulness. Among persons with brain injury, serotonin agents have been used for the treatment of depression, panic disorder, obsessive-compulsive disorders, agitation, sleep disorders, and motor dysfunction.

Conclusion: This article will review the mechanisms, efficacy, and side effects of serotonin agents with a focus on persons with brain injury.

Professor and Chair Department of Physical Medicine and Rehabilitation University of Pittsburgh Pittsburgh, Pennsylvania (Zafonte)

Physiatrist Assistant Professor Department of Medicine Toronto Rehabilitation Institute University of Toronto Toronto, Canada (Cullen)

Associate Professor of Experimental Neurology Director, Neuromuscular Research Laboratory Department of Rehabilitation University of Lund Lund, Sweden (Lexell)

Address correspondence and reprint requests to: Ross D. Zafonte, DO, 3471 Fifth Avenue, Suite 201, Pittsburgh, PA 15213. Telephone (412) 648-6979; Fax (412) 692-4410. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.