Selected Reviews in PsychopharmacologyPsychostimulant Use in the Rehabilitation of Individuals with Traumatic Brain InjuryWhyte, John MD, PhD; Vaccaro, Monica MS; Grieb-Neff, Patricia MA; Hart, Tessa PhDAuthor Information Director Moss Rehabilitation Research Institute Professor of Rehabilitative Medicine Thomas Jefferson University (Whyte) Project Director Moss Rehabilitation Research Institute (Vaccaro) Research Assistant Moss Rehabilitation Research Institute (Grieb-Neff) Institute Scientist Moss Rehabilitation Research Institute Philadelphia, Pennsylvania (Hart) Address correspondence and requests for reprints to John Whyte, MD, PhD, Director, Moss Rehabilitation Research Institute, 1200 West Tabor Road, Korman Bldg., Suite 211, Philadelphia, PA 19141. Telephone: (215) 456-5924. E-mail: [email protected]. Supported, in part, by grants 1R01NS39163 and 1R24HD3962101 from the National Institutes of Health, Bethesda, Maryland. Journal of Head Trauma Rehabilitation: August 2002 - Volume 17 - Issue 4 - p 284-299 Buy Abstract Background: Psychostimulants are used commonly in the rehabilitation of individuals with traumatic brain injury (TBI), despite the dearth of well-controlled studies of their effects. The available literature suggests that these drugs predominantly affect the speed of cognitive processing and certain observational ratings of mood and behavior. Effects on sustained attention, distractibility, and memory are less clear. Objective: This article reviews the controlled research literature on the use of these drugs in TBI and presents preliminary data from the authors' laboratory that extends these findings. Some of the common research pitfalls that have limited progress in research on these drugs are discussed. © 2002 Lippincott Williams & Wilkins, Inc.