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A Differential Diagnostic Approach to the Pharmacological Treatment of Cognitive, Behavioral, and Affective Disorders After Traumatic Brain Injury

Glenn, Mel B. MD

The Journal of Head Trauma Rehabilitation: August 2002 - Volume 17 - Issue 4 - p 273–283
Selected Reviews in Psychopharmacology

The choice of pharmacologic treatment for cognitive, behavioral, or affective disorders following TBI depends upon an accurate assessment of the underlying disorder responsible for the clinical picture presented. However there are a myriad of possible causes for each sign or symptom, and often several contributing factors. A differential diagnostic approach is presented that structures the search for etiology into several categories: preinjury diagnosis, neuropsychological disorders, sensorimotor disorder, medical disorders, adverse effects of medications, reactive mood and anxiety disorders, and sleep disorders.

Director of Outpatient and Community Brain Injury Rehabilitation Spaulding Rehabilitation Hospital Associate Professor Department of Physical Medicine and Rehabilitation Harvard Medical School Boston, Massachusetts

Address correspondence and requests for reprints to Mel B. Glenn, MD, Director of Outpatient and Community Brain Injury Rehabilitation, Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, MA 02114. Telephone: (617) 573-2625. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.