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Pericoital Oral Contraception With Levonorgestrel: A Systematic Review

Raymond, Elizabeth G. MD, MPH; Halpern, Vera MD; Lopez, Laureen M. PhD

doi: 10.1097/AOG.0b013e318209dc25

OBJECTIVE: To determine the effectiveness and safety of repeated precoital and postcoital use of levonorgestrel for pregnancy prevention.

DATA SOURCES: We searched eight computerized databases for studies that evaluated oral hormones taken for contraception immediately before or after each coital act during one or more menstrual cycles. We reviewed reference lists and contacted experts.

METHODS OF STUDY SELECTION: Of 31 studies identified, we excluded 16 from this review because they contained incomplete information on the drug regimen, number of pregnancies, or duration of follow-up or because they did not evaluate levonorgestrel. The remaining 15 studies collectively included 20 groups of women treated with levonorgestrel: 10 groups received 0.75 mg and 10 received other doses.

TABULATION, INTEGRATION, AND RESULTS: Two authors independently extracted data from the included studies. We calculated Pearl indices from individual studies and pooled data and estimated confidence intervals (CIs) using a Poisson distribution. Most studies had methodological limitations. The studies of the 0.75-mg levonorgestrel dose included 2,628 patients who used the method for 1,033 woman-years and yielded a pooled Pearl index of 5.1 pregnancies per 100 woman-years (95% CI 3.8–6.7). The studies of other doses added 5,787 patients who used the method for 53,347 cycles. The pooled Pearl index for all studies was 4.9 pregnancies per 100 woman-years (95% CI 4.3–5.5). The main side effect was frequent menstrual irregularities. No serious adverse events were reported. Most women liked the pericoital method.

CONCLUSION: The data suggested that pericoital oral levonorgestrel is safe and moderately effective. However, the quality of the studies was suboptimal. A pressing need exists for rigorous research to evaluate pericoital use of levonorgestrel as a primary means of contraception.

Pericoital use of oral levonorgestrel appears to be safe and effective for contraception.

From Gynuity Health Projects, New York, New York; and Family Health International, Research Triangle Park, North Carolina.

Support for this study was provided by Family Health International (FHI) with funds from the Hewlett Foundation and the National Institute of Child Health and Human Development. The views expressed in this article do not necessarily reflect those of these three organizations.

Corresponding author: Elizabeth G. Raymond, MD, MPH, Gynuity Health Projects, 15 East 26th Street, New York, NY 10010; e-mail:

Financial Disclosure Dr. Raymond has received payment for consultation with a drug company that wishes to market a pericoital oral contraceptive containing levonorgestrel. She has also received research support from this same company. She has been a consultant for Family Health International, which receives research support from this company. Dr. Halpern has received research support from a drug company that wishes to market a pericoital oral contraceptive containing levonorgestrel. Dr. Lopez did not report any potential conflicts of interest.

© 2011 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.