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ACOG Publications

ACOG Committee Opinion No. 727 Summary: Cascade Testing: Testing Women For Known Hereditary Genetic Mutations Associated With Cancer

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doi: 10.1097/AOG.0000000000002451
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Recommendations and Conclusions

The American College of Obstetricians and Gynecologists makes the following recommendations and conclusions regarding genetic cascade testing for hereditary gynecologic cancer:

  • Cascade testing refers to the performance of genetic counseling and testing in blood relatives of individuals who have been identified with specific genetic mutations. Testing protocols and interventions may save lives and improve health and quality of life for these family members.
  • Cascade testing has been shown to be cost effective in part because testing for specific mutations (eg, those identified in the affected relative) is less expensive than whole-gene sequencing.
  • Obstetrician–gynecologists should know who is eligible for cascade testing and should use all available resources to ensure that cascade testing is offered and occurs in a timely manner.
  • Obstetrician–gynecologists should be aware of the potential barriers to cascade testing and should know which options can help patients overcome those barriers.
  • Obstetrician–gynecologists should understand and participate in public health efforts to increase cascade testing for hereditary gynecologic cancer.

© 2017 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.