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Saturday, January 11, 2014

Trailers (71): Good perinatal outcome after IVF

Kissin et al. Number of embryos transferred after in vitro fertilization and good perinatal outcome

Why should you read about this topic?

It’s no longer good enough to define success with ART as a liveborn child(ren)—good perinatal outcome is the outcome of interest.

What were the authors trying to do?

Explore the association between number of embryos transferred and good perinatal outcome

Who participated and in what setting?

US women (N=82,508) undergoing ART with unfrozen autologous embryos in 2011

What was the study design?

Retrospective population-based (National ART Surveillance System)

What were the main outcome measures?

Birth at term of a singleton weighing at least 2500 g (good perinatal outcome)

What were the results?

In good prognosis women <35 years of age, transfer of a single day-3 or day-5 embryo is associated with a higher rate of good perinatal outcome.

What is the most interesting image in the paper?

Figure 1

What were the study strengths and weaknesses?

Strengths: population-based; current; thoughtful development of categories for prognosis.   Weaknesses: retrospective database study.

What does the study contribute for your practice?

Elective single embryo transfer is best for good prognosis patients