To evaluate the effect of a healthy lifestyle package (an antenatal behavior change intervention supported by smartphone application technology) on the incidence of gestational diabetes mellitus (GDM) in overweight and obese women.
Women with body mass indexes (BMIs) 25–39.9 were enrolled into this randomized controlled trial. The intervention consisted of specific dietary and exercise advice that addressed behavior change supported by a tailor-designed smartphone application. Women in the control group received usual care. The primary outcome was the incidence of GDM at 28–30 weeks of gestation. To reduce GDM from 15% to 7.2%, we estimated that 506 women would be required to have 80% power to detect this effect size at a significance of .05, that is, 253 in each group.
Between March 2013 and February 2016, 565 women were recruited with a mean BMI of 29.3 and mean gestational age of 15.5 weeks. The incidence of GDM did not differ between the two groups, 37 of 241 (15.4%) in the intervention group compared with 36 of 257 (14.1%) in the control group (relative risk 1.1, 95% CI 0.71–1.66, P=.71).
A mobile health-supported behavioral intervention did not decrease the incidence of GDM.
ISRCTN registry, https://www.isrctn.com/, ISRCTN29316280.
A behavioral intervention in pregnancy does not decrease the incidence of gestational diabetes mellitus but positively influences maternal exercise participation and dietary glycemic load.
UCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, the UCD Institute of Food and Health, UCD CSTAR, and the School of Public Health, Physical & Sports Sciences, Health Sciences Centre, University College Dublin, Dublin, the Department of Management & Marketing, University College Cork, Cork, and the Department of Endocrinology, St. Vincent's University Hospital, and the Department of Endocrinology, National Maternity Hospital, Dublin, Ireland.
Corresponding author: Fionnuala M. McAuliffe, FRCOG, FRCPI, Chair and Professor of Obstetrics & Gynaecology, University College Dublin Head, Women's and Children's Health, University College Dublin University College Dublin, National Maternity Hospital, Holles Street, D2, Dublin, Ireland; email: email@example.com.
This trial was funded by the National Maternity Hospital medical fund. The funding source did not have a role in the trial design or manuscript preparation.
Financial Disclosure The authors did not report any potential conflicts of interest.
Presented at the Society for Reproductive Investigation, March 15–18, 2017, Orlando, Florida; and at the British Society for Maternal Fetal Medicine, March 30–31, 2017, Amsterdam, the Netherlands.
The authors thank the mothers of the National Maternity Hospital who participated in the study.
Each author has indicated that he or she has met the journal's requirements for authorship.